학술논문
Engineered stem cells targeting multiple cell surface receptors in tumors
Document Type
Article
Author
Source
Stem Cells; January 2020, Vol. 38 Issue: 1 p34-44, 11p
Subject
Language
ISSN
10665099; 15494918
Abstract
Multiple stem cell types exhibit inherent tropism for cancer, and engineered stem cells have been used as therapeutic agents to specifically target cancer cells. Recently, stem cells have been engineered to target multiple surface receptors on tumor cells, as well as endothelial and immune cells in the tumor microenvironment. In this review, we discuss the rationales and strategies for developing multiple receptor‐targeted stem cells, their mechanisms of action, and the promises and challenges they hold as cancer therapeutics.