학술논문
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Document Type
Article
Author
Voysey, Merryn; Clemens, Sue Ann Costa; Madhi, Shabir A; Weckx, Lily Y; Folegatti, Pedro M; Aley, Parvinder K; Angus, Brian; Baillie, Vicky L; Barnabas, Shaun L; Bhorat, Qasim E; Bibi, Sagida; Briner, Carmen; Cicconi, Paola; Collins, Andrea M; Colin-Jones, Rachel; Cutland, Clare L; Darton, Thomas C; Dheda, Keertan; Duncan, Christopher J A; Emary, Katherine R W; Ewer, Katie J; Fairlie, Lee; Faust, Saul N; Feng, Shuo; Ferreira, Daniela M; Finn, Adam; Goodman, Anna L; Green, Catherine M; Green, Christopher A; Heath, Paul T; Hill, Catherine; Hill, Helen; Hirsch, Ian; Hodgson, Susanne H C; Izu, Alane; Jackson, Susan; Jenkin, Daniel; Joe, Carina C D; Kerridge, Simon; Koen, Anthonet; Kwatra, Gaurav; Lazarus, Rajeka; Lawrie, Alison M; Lelliott, Alice; Libri, Vincenzo; Lillie, Patrick J; Mallory, Raburn; Mendes, Ana V A; Milan, Eveline P; Minassian, Angela M; McGregor, Alastair; Morrison, Hazel; Mujadidi, Yama F; Nana, Anusha; O’Reilly, Peter J; Padayachee, Sherman D; Pittella, Ana; Plested, Emma; Pollock, Katrina M; Ramasamy, Maheshi N; Rhead, Sarah; Schwarzbold, Alexandre V; Singh, Nisha; Smith, Andrew; Song, Rinn; Snape, Matthew D; Sprinz, Eduardo; Sutherland, Rebecca K; Tarrant, Richard; Thomson, Emma C; Török, M Estée; Toshner, Mark; Turner, David P J; Vekemans, Johan; Villafana, Tonya L; Watson, Marion E E; Williams, Christopher J; Douglas, Alexander D; Hill, Adrian V S; Lambe, Teresa; Gilbert, Sarah C; Pollard, Andrew J; Aban, Marites; Abayomi, Fatola; Abeyskera, Kushala; Aboagye, Jeremy; Adam, Matthew; Adams, Kirsty; Adamson, James; Adelaja, Yemi A.; Adewetan, Gbadebo; Adlou, Syed; Ahmed, Khatija; Akhalwaya, Yasmeen; Akhalwaya, Saajida; Alcock, Andrew; Ali, Aabidah; Allen, Elizabeth R.; Allen, Lauren; Almeida, Thamires C. D. S. C; Alves, Mariana P.S.; Amorim, Fabio; Andritsou, Foteini; Anslow, Rachel; Appleby, Matthew; Arbe-Barnes, Edward H.; Ariaans, Mark P.; Arns, Beatriz; Arruda, Laiana; Azi, Paula; Azi, Lorena; Babbage, Gavin; Bailey, Catherine; Baker, Kenneth F.; Baker, Megan; Baker, Natalie; Baker, Philip; Baldwin, Lisa; Baleanu, Ioana; Bandeira, Danieli; Bara, Anna; Barbosa, Marcella A.S.; Barker, Debbie; Barlow, Gavin D.; Barnes, Eleanor; Barr, Andrew S.; Barrett, Jordan R.; Barrett, Jessica; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beales, Emily; Beckley, Rebecca; Belij-Rammerstorfer, Sandra; Bell, Jonathan; Bellamy, Duncan; Bellei, Nancy; Belton, Sue; Berg, Adam; Bermejo, Laura; Berrie, Eleanor; Berry, Lisa; Berzenyi, Daniella; Beveridge, Amy; Bewley, Kevin R.; Bexhell, Helen; Bhikha, Sutika; Bhorat, Asad E.; Bhorat, Zaheda E.; Bijker, Else; Birch, Geeta; Birch, Sarah; Bird, Adam; Bird, Olivia; Bisnauthsing, Karen; Bittaye, Mustapha; Blackstone, Katherine; Blackwell, Luke; Bletchly, Heather; Blundell, Caitlin L.; Blundell, Susannah R.; Bodalia, Pritesh; Boettger, Bruno C.; Bolam, Emma; Boland, Elena; Bormans, Daan; Borthwick, Nicola; Bowring, Francesca; Boyd, Amy; Bradley, Penny; Brenner, Tanja; Brown, Phillip; Brown, Claire; Brown-O'Sullivan, Charlie; Bruce, Scott; Brunt, Emily; Buchan, Ruaridh; Budd, William; Bulbulia, Yusuf A.; Bull, Melanie; Burbage, Jamie; Burhan, Hassan; Burn, Aileen; Buttigieg, Karen R.; Byard, Nicholas; Cabera Puig, Ingrid; Calderon, Gloria; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Cardoso, João R.; Carr, Melanie; Carroll, Miles W.; Carson-Stevens, Andrew; Carvalho, Yasmin de M.; Carvalho, José A.M.; Casey, Helen R.; Cashen, Paul; Castro, Thais; Castro, Lucia Carratala; Cathie, Katrina; Cavey, Ana; Cerbino-Neto, José; Chadwick, Jim; Chapman, David; Charlton, Sue; Chelysheva, Irina; Chester, Oliver; Chita, Sunder; Cho, Jee-Sun; Cifuentes, Liliana; Clark, Elizabeth; Clark, Matthew; Clarke, Andrea; Clutterbuck, Elizabeth A.; Collins, Sarah L.K.; Conlon, Christopher P.; Connarty, Sean; Coombes, Naomi; Cooper, Cushla; Cooper, Rachel; Cornelissen, Lynne; Corrah, Tumena; Cosgrove, Catherine; Cox, Tony; Crocker, Wendy E.M.; Crosbie, Sarah; Cullen, Lorraine; Cullen, Dan; Cunha, Debora R.M.F.; Cunningham, Christina; Cuthbertson, Fiona C.; Da Guarda, Suzete N. Farias; da Silva, Larissa P.; Damratoski, Brad E.; Danos, Zsofia; Dantas, Maria T.D.C.; Darroch, Paula; Datoo, Mehreen S.; Datta, Chandrabali; Davids, Malika; Davies, Sarah L.; Davies, Hannah; Davis, Elizabeth; Davis, Judith; Davis, John; De Nobrega, Maristela M.D.; De Oliveira Kalid, Lis Moreno; Dearlove, David; Demissie, Tesfaye; Desai, Amisha; Di Marco, Stefania; Di Maso, Claudio; Dinelli, Maria I.S.; Dinesh, Tanya; Docksey, Claire; Dold, Christina; Dong, Tao; Donnellan, Francesca R.; Dos Santos, Tannyth; dos Santos, Thainá G.; Dos Santos, Erika Pachecho; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Driver, Kimberley; Drury, Ruth; Dunachie, Susanna J.; Durham, Benjamin S.; Dutra, Lidiana; Easom, Nicholas J.W.; van Eck, Samual; Edwards, Mandy; Edwards, Nick J.; El Muhanna, Omar M.; Elias, Sean C.; Elmore, Mike; English, Marcus; Esmail, Alisgair; Essack, Yakub Moosa; Farmer, Eoghan; Farooq, Mutjaba; Farrar, Madi; Farrugia, Leonard; Faulkner, Beverley; Fedosyuk, Sofiya; Felle, Sally; Feng, Shuo; Ferreira Da Silva, Carla; Field, Samantha; Fisher, Richard; Flaxman, Amy; Fletcher, James; Fofie, Hazel; Fok, Henry; Ford, Karen J.; Fowler, Jamie; Fraiman, Pedro H.A.; Francis, Emma; Franco, Marilia M.; Frater, John; Freire, Marilúcia S.M.; Fry, Samantha H.; Fudge, Sabrina; Furze, Julie; Fuskova, Michelle; Galian-Rubio, Pablo; Galiza, Eva; Garlant, Harriet; Gavrila, Madita; Geddes, Ailsa; Gibbons, Karyna A.; Gilbride, Ciaran; Gill, Hardeep; Glynn, Sharon; Godwin, Kerry; Gokani, Karishma; Goldoni, Ursula Carvalho; Goncalves, Maria; Gonzalez, Isabela G.S.; Goodwin, Jayne; Goondiwala, Amina; Gordon-Quayle, Katherine; Gorini, Giacomo; Grab, Janet; Gracie, Lara; Greenland, Melanie; Greenwood, Nicola; Greffrath, Johann; Groenewald, Marisa M.; Grossi, Leonardo; Gupta, Gaurav; Hackett, Mark; Hallis, Bassam; Hamaluba, Mainga; Hamilton, Elizabeth; Hamlyn, Joseph; Hammersley, Daniel; Hanrath, Aidan T.; Hanumunthadu, Brama; Harris, Stephanie A.; Harris, Clair; Harris, Tara; Harrison, Thomas D.; Harrison, Daisy; Hart, Thomas C.; Hartnell, Birgit; Hassan, Shadin; Haughney, John; Hawkins, Sophia; Hay, Jodie; Head, Ian; Henry, John; Hermosin Herrera, Macarena; Hettle, David B.; Hill, Jennifer; Hodges, Gina; Horne, Elizea; Hou, Mimi M.; Houlihan, Catherine; Howe, Elizabeth; Howell, Nicola; Humphreys, Jonathan; Humphries, Holly E.; Hurley, Katrina; Huson, Claire; Hyder-Wright, Angela; Hyams, Catherine; Ikram, Sabina; Ishwarbhai, Alka; Ivan, Monica; Iveson, Poppy; Iyer, Vidyashankara; Jackson, Frederic; De Jager, Jeanne; Jaumdally, Shameem; Jeffers, Helen; Jesudason, Natasha; Jones, Bryony; Jones, Kathryn; Jones, Elizabeth; Jones, Christopher; Jorge, Marianna Rocha; Jose, Aylin; Joshi, Amar; Júnior, Eduardo A.M.S.; Kadziola, Joanne; Kailath, Reshma; Kana, Faeeza; Karampatsas, Konstantinos; Kasanyinga, Mwila; Keen, Jade; Kelly, Elizabeth J.; Kelly, Dearbhla M.; Kelly, Debbie; Kelly, Sarah; Kerr, David; Kfouri, Renato de Ávila; Khan, Liaquat; Khozoee, Baktash; Kidd, Sarah; Killen, Annabel; Kinch, Jasmin; Kinch, Patrick; King, Lloyd D.W.; King, Thomas B.; Kingham, Lucy; Klenerman, Paul; Knapper, Francesca; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Lang, Matilda; Lang, Gail; Larkworthy, Colin W.; Larwood, Jessica P.J.; Law, Rebecca; Lazarus, Erica M.; Leach, Amanda; Lees, Emily A.; Lemm, Nana-Marie; Lessa, Alvaro; Leung, Stephanie; Li, Yuanyuan; Lias, Amelia M.; Liatsikos, Kostas; Linder, Aline; Lipworth, Samuel; Liu, Shuchang; Liu, Xinxue; Lloyd, Adam; Lloyd, Stephanie; Loew, Lisa; Lopez Ramon, Raquel; Lora, Leandro; Lowthorpe, Vicki; Luz, Kleber; MacDonald, Jonathan C.; MacGregor, Gordon; Madhavan, Meera; Mainwaring, David O.; Makambwa, Edson; Makinson, Rebecca; Malahleha, Mookho; Malamatsho, Ross; Mallett, Garry; Mansatta, Kushal; Maoko, Takalani; Mapetla, Katlego; Marchevsky, Natalie G.; Marinou, Spyridoula; Marlow, Emma; Marques, Gabriela N.; Marriott, Paula; Marshall, Richard P.; Marshall, Julia L.; Martins, Flávia J.; Masenya, Masebole; Masilela, Mduduzi; Masters, Shauna K.; Mathew, Moncy; Matlebjane, Hosea; Matshidiso, Kedidimetse; Mazur, Olga; Mazzella, Andrea; McCaughan, Hugh; McEwan, Joanne; McGlashan, Joanna; McInroy, Lorna; McIntyre, Zoe; McLenaghan, Daniela; McRobert, Nicky; McSwiggan, Steve; Megson, Clare; Mehdipour, Savviz; Meijs, Wilma; Mendonça, Renata N.Á.; Mentzer, Alexander J.; Mirtorabi, Neginsadat; Mitton, Celia; Mnyakeni, Sibusiso; Moghaddas, Fiona; Molapo, Kgaogelo; Moloi, Mapule; Moore, Maria; Moraes-Pinto, M. Isabel; Moran, Marni; Morey, Ella; Morgans, Róisín; Morris, Susan; Morris, Sheila; Morris, Helen C.; Morselli, Franca; Morshead, Gertraud; Morter, Richard; Mottal, Lynelle; Moultrie, Andrew; Moya, Nathifa; Mpelembue, Mushiya; Msomi, Sibekezelo; Mugodi, Yvonne; Mukhopadhyay, Ekta; Muller, Jilly; Munro, Alasdair; Munro, Claire; Murphy, Sarah; Mweu, Philomena; Myasaki, Celia Hatsuko; Naik, Gurudutt; Naker, Kush; Nastouli, Eleni; Nazir, Abida; Ndlovu, Bongani; Neffa, Fabio; Njenga, Cecilia; Noal, Helena; Noé, Andrés; Novaes, Gabrielle; Nugent, Fay L.; Nunes, Géssika; O'Brien, Katie; O'Connor, Daniel; Odam, Miranda; Oelofse, Suzette; Oguti, Blanche; Olchawski, Victoria; Oldfield, Neil J.; Oliveira, Marianne G.; Oliveira, Catarina; Oosthuizen, Angela; O'Reilly, Paula; Osborne, Piper; Owen, David R.J.; Owen, Lydia; Owens, Daniel; Owino, Nelly; Pacurar, Mihaela; Paiva, Brenda V.B.; Palhares, Edna M.F.; Palmer, Susan; Parkinson, Sivapriyai; Parracho, Helena M.R.T.; Parsons, Karen; Patel, Dipak; Patel, Bhumika; Patel, Faeezah; Patel, Kelly; Patrick-Smith, Maia; Payne, Ruth O.; Peng, Yanchun; Penn, Elizabeth J.; Pennington, Anna; Peralta Alvarez, Marco Polo; Perring, James; Perry, Nicola; Perumal, Rubeshan; Petkar, Sahir; Philip, Tricia; Phillips, Daniel J.; Phillips, Jennifer; Phohu, Mary Kgomotso; Pickup, Lorinda; Pieterse, Sonja; Piper, Jo; Pipini, Dimitra; Plank, Mary; Du Plessis, Joan; Pollard, Samuel; Pooley, Jennifer; Pooran, Anil; Poulton, Ian; Powers, Claire; Presa, Fernando B.; Price, David A.; Price, Vivien; Primeira, Marcelo; Proud, Pamela C.; Provstgaard-Morys, Samuel; Pueschel, Sophie; Pulido, David; Quaid, Sheena; Rabara, Ria; Radford, Alexandra; Radia, Kajal; Rajapaska, Durga; Rajeswaran, Thurkka; Ramos, Alberto San Francisco; Ramos Lopez, Fernando; Rampling, Tommy; Rand, Jade; Ratcliffe, Helen; Rawlinson, Tom; Rea, David; Rees, Byron; Reiné, Jesús; Resuello-Dauti, Mila; Reyes Pabon, Emilia; Ribiero, Carla M.; Ricamara, Marivic; Richter, Alex; Ritchie, Neil; Ritchie, Adam J.; Robbins, Alexander J.; Roberts, Hannah; Robinson, Ryan E.; Robinson, Hannah; Rocchetti, Talita T.; Rocha, Beatriz Pinho; Roche, Sophie; Rollier, Christine; Rose, Louisa; Ross Russell, Amy L.; Rossouw, Lindie; Royal, Simon; Rudiansyah, Indra; Ruiz, Sarah; Saich, Stephen; Sala, Claudia; Sale, Jessica; Salman, Ahmed M.; Salvador, Natalia; Salvador, Stephannie; Sampaio, Milla; Samson, Annette D.; Sanchez-Gonzalez, Amada; Sanders, Helen; Sanders, Katherine; Santos, Erika; Santos Guerra, Mayara F.S.; Satti, Iman; Saunders, Jack E.; Saunders, Caroline; Sayed, Aakifah; Schim van der Loeff, Ina; Schmid, Annina B.; Schofield, Ella; Screaton, Gavin; Seddiqi, Samiullah; Segireddy, Rameswara R.; Senger, Roberta; Serrano, Sonia; Shah, Rajiv; Shaik, Imam; Sharpe, Hannah E.; Sharrocks, Katherine; Shaw, Robert; Shea, Adam; Shepherd, Amy; Shepherd, James G.; Shiham, Farah; Sidhom, Emad; Silk, Sarah E.; da Silva Moraes, Antonio Carlos; Silva-Junior, Gilberto; Silva-Reyes, Laura; Silveira, Anderson D.; Silveira, Mariana B.V.; Sinha, Jaisi; Skelly, Donal T.; Smith, Daniel C.; Smith, Nick; Smith, Holly E.; Smith, David J.; Smith, Catherine C.; Soares, Airanuédida; Soares, Tiago; Solórzano, Carla; Sorio, Guilherme L.; Sorley, Kim; Sosa-Rodriguez, Tiffany; Souza, Cinthia M.C.D.L.; Souza, Bruno S.D.F.; Souza, Alessandra R.; Spencer, Alexandra J.; Spina, Fernanda; Spoors, Louise; Stafford, Lizzie; Stamford, Imogen; Starinskij, Igor; Stein, Ricardo; Steven, Jill; Stockdale, Lisa; Stockwell, Lisa V.; Strickland, Louise H.; Stuart, Arabella C.; Sturdy, Ann; Sutton, Natalina; Szigeti, Anna; Tahiri-Alaoui, Abdessamad; Tanner, Rachel; Taoushanis, Carol; Tarr, Alexander W.; Taylor, Keja; Taylor, Ursula; Taylor, Iona Jennifer; Taylor, Justin; te Water Naude, Rebecca; Themistocleous, Yrene; Themistocleous, Andreas; Thomas, Merin; Thomas, Kelly; Thomas, Tonia M.; Thombrayil, Asha; Thompson, Fawziyah; Thompson, Amber; Thompson, Kevin; Thompson, Ameeka; Thomson, Julia; Thornton-Jones, Viv; Tighe, Patrick J.; Tinoco, Lygia Accioly; Tiongson, Gerlynn; Tladinyane, Bonolo; Tomasicchio, Michele; Tomic, Adriana; Tonks, Susan; Towner, James; Tran, Nguyen; Tree, Julia; Trillana, Gerry; Trinham, Charlotte; Trivett, Rose; Truby, Adam; Tsheko, Betty Lebogang; Turabi, Aadil; Turner, Richard; Turner, Cheryl; Ulaszewska, Marta; Underwood, Benjamin R.; Varughese, Rachel; Verbart, Dennis; Verheul, Marije; Vichos, Iason; Vieira, Taiane; Waddington, Claire S.; Walker, Laura; Wallis, Erica; Wand, Matthew; Warbick, Deborah; Wardell, Theresa; Warimwe, George; Warren, Sarah C.; Watkins, Bridget; Watson, Ekaterina; Webb, Stewart; Webb-Bridges, Alice; Webster, Angela; Welch, Jessica; Wells, Jeanette; West, Alison; White, Caroline; White, Rachel; Williams, Paul; Williams, Rachel L.; Winslow, Rebecca; Woodyer, Mark; Worth, Andrew T.; Wright, Danny; Wroblewska, Marzena; Yao, Andy; Zimmer, Rafael; Zizi, Dalila; Zuidewind, Peter
Source
The Lancet; January 2021, Vol. 397 Issue: 10269 p99-111, 13p
Subject
Language
ISSN
01406736; 1474547X
Abstract
A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials.