학술논문
Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial
Document Type
Article
Author
Menon, Bijoy K; Buck, Brian H; Singh, Nishita; Deschaintre, Yan; Almekhlafi, Mohammed A; Coutts, Shelagh B; Thirunavukkarasu, Sibi; Khosravani, Houman; Appireddy, Ramana; Moreau, Francois; Gubitz, Gord; Tkach, Aleksander; Catanese, Luciana; Dowlatshahi, Dar; Medvedev, George; Mandzia, Jennifer; Pikula, Aleksandra; Shankar, Jai; Williams, Heather; Field, Thalia S; Manosalva, Alejandro; Siddiqui, Muzaffar; Zafar, Atif; Imoukhuede, Oje; Hunter, Gary; Demchuk, Andrew M; Mishra, Sachin; Gioia, Laura C; Jalini, Shirin; Cayer, Caroline; Phillips, Stephen; Elamin, Elsadig; Shoamanesh, Ashkan; Subramaniam, Suresh; Kate, Mahesh; Jacquin, Gregory; Camden, Marie-Christine; Benali, Faysal; Alhabli, Ibrahim; Bala, Fouzi; Horn, MacKenzie; Stotts, Grant; Hill, Michael D; Gladstone, David J; Poppe, Alexandre; Sehgal, Arshia; Zhang, Qiao; Lethebe, Brendan Cord; Doram, Craig; Ademola, Ayoola; Shamy, Michel; Kenney, Carol; Sajobi, Tolulope T; Swartz, Richard H; Srivastava, Abhilekh; Aljammaz, Ahmed M; Akindotun, Akintomide Femi; Jin, Albert Y; Fraser, Alexander; Khaw, Alexander V; Lemnaru, Alexandru; Southwell, Alisia; Ramji, Alnar; Alvarado-Bolaños, Alonso; Mouminah, Amr; Lahlouh, Amro B; Yu, Amy Y; Alrohimi, Anas; Lavoie, Andre; Rogge, Andrea; Micieli, Andrew; Nguyen, Andrew Linh; Callaghan-Brown, Angelique; Florendo-Cumbermack, Anita; Wadhwa, Ankur; Beaudoin, Ann-Marie; Cayley, Anne; Liddy, Anne Marie; Trivedi, Anurag; Katsanos, Aristeidis H; Shuaib, Ashfaq; Butt, Asif Javed; Bereznyakova, Olena; Beauchamp, Beth; Mahlitz, Breane; Graham, Brett R; Dewar, Brian; Buck, Brian H; Durafourt, Bryce A; Holtby, Caitlin; Jackson-Tarlton, Caitlin S; Bockus, Caitlyn; Stephenson, Caroline; Galloway, Camille; Odier, Céline; Deacon, Charles; Zerna, Charlotte; Vekhande, Chetan C; Bocti, Christian; Stapf, Christian; Hawkes, Christine; Stables, Christine Anne; Bogiatzi, Chrysi; Rodriguez, Claudia; Candale-Radu, Claudia; Murphy, Colleen; Casserly, Courtney Sarah; Fok, Daniel; Boasquevisque, Danielle de Sa; Wile, Daryl; Volders, David; Sahlas, Demetrios J; Shand, Elaine; Cora, Elena Adela; Battista, Eliane Di; Stewart, Eileen; Junk, Emily; Harrison, Emma L; Frenette, Eric; Teleg, Ericka; Abdellah, Eslam; Ghrooda, Esseddeeg; Akthar, Farhana; Evoy, François; Klein, Gary M; Maclean, Genoveva; Jickling, Glen C; Hawthorne, Glenda; Boyd, Gordon; Walker, Gregory; Saposnik, Gustavo; Lau, H Lee; Badr, Hanan E; Toma, Hassanain; Kalashyan, Hayrapet; Marion-Moffet, Hugo; Grant, Ian; Fatakdawala, Idris; Beaulieu-Boire, Isabelle; Williams, Janice; Brar, Jaskiran; Rivest, Jean; Wang, Jeffrey Z; Dawe, Jessica; Stang, Jillian; Day, Joanne; Miller, Jodi; Gorman, Johnathon; Hopyan, Julia Jasmine; Lee, Julian; Kromm, Julie; Foster, Kaitlyn; Ratnayake, Kanchana; Perera, Kanjana S; Murray, Karina Villaluna; Ryckborst, Karla; Lin, Katie; Sage, Kayla; Sivakuma, Keithan; MacDonald, Kelly A; Ng, Kelvin Kuan; Merchant, Ketki; Khan, Khurshid; Ghavami, Kimia; Johnston, Kyra; Mai, Lauren M; White, Leah; Barratt, Lee; Longpre, Linda; Crellin, Lisa; Peeling, Lissa; Piquette, Lori; Lomax, Lysa Boissé; Sadeghi, Mahsa; Kamra, Maneesha; Lavoie-April, Manuel; Moores, Margaret; Bullrich, Maria Bres; McClelland, Marie; Salluzzi, Marina; Wilcox, Mark; Boulos, Mark I; Marko, Martha; Boyko, Matthew; Lantagne-Hurtubise, Maude; AlHamid, May Adel; Shawawrah, Mays; Kelly, Michael E; Thorne, Michael W D; Shamy, Michel; Bussiere, Miguel; Dominc Tse, Ming Yin; Benguzzi, Mowad; Sharma, Mukul; Horton, Myles; Newcommon, Nancy; Simon, Nandy-Shelwine; Parks, Natalie E; Sultan, Nazeem; Markovic, Nevena; Daneault, Nicole; Ishaque, Noman; Fairall, Paige; Kostyrko, Pawel B; Stys, Peter K; Teal, Philip; Couillard, Philippe; King-Azote, Princess; Collier, Quentin; Epp, Rachel; Nair, Radhika; Joundi, Raed A; Jassal, Rajive; Schneider, Raphael; Hosseini, Reza; Bouchard, Rosalie; Whelan, Ruth; Cooley, S Regan; Sujanthan, Sajeevan; Mansoor, Salman; Yip, Samuel; Wasyliw, Sanchea; Taylor, Sean W.; Friedman, Sebastian; Mann, Sharan; Maley, Sharleen Weese; Chiasson, Sherry; Hu, Sherry Xueying; Althubait, Shorog; Himed, Shuhira; Chen, Shuo; Bal, Simerpreet S; Page, Stacey A; Beck, Stacey D; Woodroffe, Stephanie; Reiter, Stephanie D; Gaal, Stephen van; Peters, Steven Ray; Darvesh, Sultan; Save, Supriya; Alcock, Susan; Piercey, Susannah; Adam, Suzie; Gosselin, Sylvie; Fitzpatrick, Tess; Perron, Thomas-Louis; Stewart, Tim; Benstead, Timothy J; Naidoo, Vishaya; Wahab, Wasan Abd; Oczkowski, Wiesław; Kingston, William; Leduc, William; To, William T H; Yu, Yeyao Joe; Liu, Zhongyu A; Aljundi, Ziad Ezzat
Source
The Lancet; July 2022, Vol. 400 Issue: 10347 p161-169, 9p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Intravenous thrombolysis with alteplase bolus followed by infusion is a global standard of care for patients with acute ischaemic stroke. We aimed to determine whether tenecteplase given as a single bolus might increase reperfusion compared with this standard of care.