학술논문
Synthesis and Biological Evaluation of 18-Methoxycoronaridine Congeners. Potential Antiaddiction Agents
Document Type
Article
Author
Source
Journal of Medicinal Chemistry; June 2003, Vol. 46 Issue: 13 p2716-2730, 15p
Subject
Language
ISSN
00222623; 15204804
Abstract
Variation of the methoxycarbonyl and C-18 substituents of the antiaddictive compound 18-methoxycoronaridine, and contraction of its isoquinuclidine ring segment, provided 15 congeners for SAR evaluation at opioid and α3β4 nicotinic acetylcholine receptors. The opioid activities were relatively low, and the α3β4 nicotinic acetylcholine receptor activities were found to correlate with in vivo antiaddictive activities.