학술논문
Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing
Document Type
Article
Author
Source
Molecular and Cellular Proteomics (MCP Online); August 2020, Vol. 19 Issue: 8 p1281-1302, 22p
Subject
Language
ISSN
15359476; 15359484
Abstract
Oligodendrocyte progenitor cell (OPC)-mediated remyelination declines with ageing. We have determined the proteome of neonatal, young and aged rat OPCs using quantitative MS-proteomics. We identify increases in myelin proteins as well as changes in inflammation, cholesterol biosynthesis and protein homeostasis pathways in OPCs with ageing. These data provide a resource to study age-associated changes in OPCs that may contribute to the age-related decrease in oligodendrogliogenesis.