학술논문
Human DOCK11 Deficiency Causes Defective Erythropoiesis and Systemic Inflammation
Document Type
Article
Author
Block, Jana; Rashkova, Christina; Castanon, Irinka; Platon, Jessica; Zoghi, Samaneh; Fujiwara, Mitsuhiro; Chaves, Beatriz; Schoppmeyer, Rouven; Van Der Made, Caspar; Cabrera-Perez, Rocio; Harms, Frederike Leonie; Ardy, Rico Chandra; Alavi, Samin; Alsina, Laia; Avila Polo, Rainiero; Sanchez Moreno, Paula; Jimenez Heredia, Raul; Hannich, Thomas; Huppa, Johannes; Distel, Martin; Pickl, Winfried; Yoder, Jeffrey; Traver, David; Engelhardt, Karin; Linden, Tobias; Kager, Leo; Hambleton, Sophie; Hoischen, Alexander; Illsinger, Sabine; Chavoshzadeh, Zahra; Kutsche, Kerstin; Da Costa, Lydie; Van Buul, Jaap; Calzada-Hernandez, Joan; Anton, Jordi; Neth, Olaf; Viaud, Julien; Nishikimi, Akihiko; Dupre, Loic; Boztug, Kaan
Source
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p4107-4107, 1p
Subject
Language
ISSN
00064971; 15280020
Abstract
Erythropoiesis involves significant changes in the cells, which are mediated by the plasma membrane and the actin cytoskeleton. The composition of the actin cytoskeleton and the interaction between its components are dynamically modified during erythropoiesis, however the precise role that different actin regulators play during erythroid differentiation is poorly understood.