학술논문
Identification of 4,5-Dihydro-4-hydroxygeldanamycins As Shunt Products of Geldanamycin Biosynthesis
Document Type
Article
Author
Source
Journal of Natural Products; August 2012, Vol. 75 Issue: 8 p1480-1484, 5p
Subject
Language
ISSN
01633864; 15206025
Abstract
Two new geldanamycin (GDM) analogues, (4S)-4,5-dihydro-4-hydroxygeldanamycin (1) and (4R)-4,5-dihydro-4-hydroxygeldanamycin (2), were identified from Streptomyces hygroscopicus17997. Compounds 1and 2were not normal intermediates of GDM biosynthesis but shunt products of C-4,5 oxidation catalyzed by GdmP, a cytochrome P450 oxidase acting as a desaturase in GDM biosynthesis. Preliminary assays implied that, compared with GDM, 1and 2exhibited decreased cytotoxicity.