학술논문
Efficacy and safety of intramuscular administration of tixagevimab–cilgavimab for early outpatient treatment of COVID-19 (TACKLE): a phase 3, randomised, double-blind, placebo-controlled trial
Document Type
Article
Author
Montgomery, Hugh; Hobbs, F D Richard; Padilla, Francisco; Arbetter, Douglas; Templeton, Alison; Seegobin, Seth; Kim, Kenneth; Campos, Jesus Abraham Simón; Arends, Rosalinda H; Brodek, Bryan H; Brooks, Dennis; Garbes, Pedro; Jimenez, Julieta; Koh, Gavin C K W; Padilla, Kelly W; Streicher, Katie; Viani, Rolando M; Alagappan, Vijay; Pangalos, Menelas N; Esser, Mark T; Abe, Wakana; Adan De Varona, Tania; Adiatullina, Daria; Aguilar Zapata, Daniel; Ahlers, Kevin; Aimo, Carolina; Akere, Ayoade; Akimova, Elena; Alatorre Alexander, Jorge; Aldrich, Logan; Ali Garcia, Ismael; Ali García, Karim; Allison, Lee; Alonso Zuñiga, Rosa; Aloysius, Ivan; Altclas, Javier; Alvarisqueta, Andres; Antila, Martti; Anton, Camila; Árboix Alamo, Elisabet; Arora, Samir; Avilés Felix, Ramón Alejandro; Bakhtina, Natalya; Barbero-Becerra, Varenka; Barragan-Reyes, Armando; Barreira, Alejandro; Barrett, Mitchell; Beran, Jiri; Berki, Nikolett; Berki, Viktoria; Betten, Richard; Binelli, Claudia; Brunzová, Lenka; Bussolari, Cecilia; Byargeon, Karianna; Bytnar, Justyna; Camberos, Carlos; Campos Corzo, Pedro; Cannon, Grazia; Canovi, Valentina; Carla da Rosa, Simone; Moser, Ana Caroline; Carrera Rivas, Luis; Casas, Marcelo Martin; Castañeda-Méndez, Paulo; Cavalcante, Ana; Cherepova, Eugenia; Chermenskii, Alexei; Clark, Lauren; Codeluppi, Mauro; Coelho, Flavia; Contreras, Belinda; Cran, Alex; Dao, Taylor; Dharma, Chrisette; Di Castri, Cosimo; Diaz Balocchi, Victoria; Durán, Omar; Earl, Kara; Ellery, Adam; Endo, Tomoko; Everding, Andrea; Fischer, Rainald; Fonseca, Benedito; Franklin, Chelsea C.; Franz, Susan-Beatrice; Fumagalli, Anna; Galindo-Amaya, Mauricio; Galli, Mariagiulia; Gerna, Laura; Gil Ureña, Karolly; Gomes Antila, Henrikki; Gomes Maricato, Laura Ines; Goncalvez, Gabriela; Gonzalez, Martin; González-Lama, Jesús; Granier, Stephen; Granier, Jacob; Grunwald, Stephan; Guardeño-Ropero, David; Guberti, Monica; Guduri, Sridhar; Guerrero García, Carolina; Haggiagi, Jehad; Hale, Kacie; Hayashi, Toshimasa; Hermes, Maiara; Hernandez Colin, Dante; Hirai, Yuji; Hojo, Masayuki; Homma, Tetsuya; Hour, Billy; Huber, Andreas; Iacovelli, Diego; Ishibashi, Noriomi; Iwabe, Yutaro; Izumi, Shinyu; Jessen, Arne; Jessen, Heiko; Jeudy, Wilner; Jiménez Marcos, Marta; Johnson, Rebecca; Juárez-Hernández, Eva; Kabasawa, Kiyomi; Kamińska, Katarzyna; Kawabe, Megumi; Kemp, Angela; Khmelnitskiy, Oleg; Klassen, Carina; Kobrynska, Olena; Koleckar, Pavel; Korn, Stephanie; Kornmann, Marc; Kostenko, Viktor; Kovalchuk, Evgenii; Kovalchuk, Yana; Kümmerle, Tim; Lachmund, Ulrike; Lammersmann, Kerstin; Lastebasse, Flávio; Lattuada, Ivana; Lauer, Felicitas; Lebed, Kyrylo; Lebed, Olga; Lecona-Garcia, Diego; Leoni, Maria Christina; Lima, Marina; Little, Raymond; Little, Holly; Lizardi-Díaz, Andrea; Lobo-Becker, Michele; Luppi, Francesco; Macias, Veronica; Maesaki, Shigefumi; Magnaghi, Cristiano; Mancini, Annalisa; Mazur, Stanisław; Melnikova, Tatiana; Menchaca, Sergio; Menendez-Perez, Ibrahim; Międlar, Ewa; Mizunuma, Shuuichi; Mochalova, Anastasiya; Mohamed, Mihad; Moll, Theresa; Montalvo, Camila; Mottola, Amber; Mück, Birgit; Mussi Brugnolli, Rebeca; Nanda, Akanksha; Neuner, Dörthe; Ngwueke, Agatha; Noe, Sebastian; Novacek, Martin; Nuzzolo-Shihadeh, Laura; Obiekwe, Emeka; Ocampo Gaytán, Isaias G.; Ohmagari, Norio; Ohta, Shin; Onyewuchi, Ptuonye; Pankov, Iurii; Pedrosa, Maurício; Peré, Yael; Pereyra, Alejandro; Perez, Eliana; Perez-Alba, Eduardo; Perpiña Lozano, Paloma; Perrei, Tanya; Peterson, Dena; Pierroti, Ligia; Pineda-Cárdenas, Felipe; Plascencia Sanchez, Teresa; Poletti, Camila; Pomaranzi, Chiara; Portes, Lisette; Postel, Nils; Ramirez, Monica; Ramírez, Isabel; Ramirez-Baena, Miguel; Ramjee, Mahadev; Ratti, Giovanna; Reeve, Jackie; Reichert, Petr; Reichertová, Petra; Reyes Garcia, Edgar Alejandro; Ricardo, Celso; Rodríguez Rodríguez, Nicomedes; Roldán Sánchez, Jaun; Romero-Lopez, Matilde; Rosales, Tyrone; Rosales, Harvey; Roshan, Mohamed; Roshan, Simran; Rovere Querini, Patrizia; Rutter, Heather; Sachwani, Sadaf; Sagara, Hironori; Sakai, Jun; Samson, Nina; Sánchez Mijangos, José Héctor; Sánchez, Liliana; Sánchez-González, Ana; Sandford, Micko; Santana, Laura; Santos de Carvalho, Felipe; Sasao, Reiko; Sato, Lubna; Scheuermann, Elizabeth; Schmidt, Olaf; Seki, Masafumi; Shaikh, Safia; Shimada, Daishi; Shinkai, Masaharu; Shinoda, Masahiro; Smith, Jackie; Solorzano, Fernando; Soncini, Silvia; Soregine, Katalin; Sosa, Erica; Sowade, Olalekan; Špinková, Veronika; Staniford, Ruth; Steigemann, Iska; Steiner, Vivien; Strelkov, Vladimir; Suárez Pineda, Cintya R.; Suenaga, Hiroki; Suzaki, Shintaro; Swayze, Hannah; Tada, Yuji; Takeshita, Yuichiro; Takiguchi, Yasuo; Tanaka, Akihiko; Tarumoto, Norihito; Tatarintseva, Albina; Taubert, Michelle; Terenya, Elizaveta; Tinoco, César; Tomiyasu, Tomohiro; Torres-Vidal, Gladys; Trejo-Aguiar, Gabriela; Tsushima, Kenji; Tunstall, Emma; Turrà, Caterina; Valdes, Yoandy; Valencia Castro, Nelly; Visconti, Guilherme; Vitali, Giordano; Vutikullird, Apinya; Watti, Jezdancher; Werth, Doreen; Wilson, Cheyanne; Wilson, Philippe; Workman, Amy; Wörle, Pamela; Wyen, Christoph; Yamaguchi, Yoshiko; Yamamoto, Kei
Source
The Lancet Respiratory Medicine; October 2022, Vol. 10 Issue: 10 p985-996, 12p
Subject
Language
ISSN
22132600; 22132619
Abstract
Early intramuscular administration of SARS-CoV-2-neutralising monoclonal antibody combination, tixagevimab–cilgavimab, to non-hospitalised adults with mild to moderate COVID-19 has potential to prevent disease progression. We aimed to evaluate the safety and efficacy of tixagevimab–cilgavimab in preventing progression to severe COVID-19 or death.