학술논문
ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline
Document Type
Article
Author
Source
Genes & Development; 2024, Vol. 38 Issue: 3-4 p115-130, 16p
Subject
Language
ISSN
08909369; 15495477
Abstract
In this study, Alavattam et al. investigate the dynamic regulation of H3K9me3 in male meiosis and identify the germline-specific protein ATF7IP2 (MCAF2) as a novel, critical regulator of H3K9 methylation and spermatogenic heterochromatin organization. They show that ATF7IP2 spatially directs histone methyltransferase SETDB1 to control the distribution of H3K9me3, thereby regulating heterochromatin organization essential for meiotic and autosomal gene regulation, meiotic sex chromosome inactivation, the expression of transposable elements, and male fertility.