학술논문
Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression
Document Type
Article
Author
Source
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; April 2009, Vol. 150 Issue: 3 p352-358, 7p
Subject
Language
ISSN
15524841; 1552485X
Abstract
It is well established that major depressive disorder MDD is partly heritable. We present a genomewide linkage study aiming to find regions on the genome that influence the vulnerability for MDD. Our sample consists of 110 Australian and 23 Dutch pedigrees with two or more siblings affected with MDD total N 278. Linkage analysis was carried out in MERLIN. Three regions showed suggestive linkage signals. The highest LODscore of 2.1 was found on chromosome 17 at 52.6 cM along with LOD scores of 1.9 and 1.7 on chromosome 8 at 2.7 cM and chromosome 2 at 90.6 cM, respectively. The result on chromosome 8 seems most promising as two previous studies also found linkage in this region, once suggestive and once significant. The linkage peak on chromosome 17 harbors the serotonin transporter gene. In the Australian and Dutch sample, the serotonin transporter length polymorphism did not show evidence for association, thus other genes in this region or other polymorphisms in the serotonin transporter gene might be associated with MDD. Further replication is needed to establish the relevance of our linkage finding on chromosome 2. © 2008 WileyLiss, Inc.