학술논문
Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identifies European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States
Document Type
Article
Author
Source
Journal of the American Society of Nephrology; January 2022, Vol. 33 Issue: 1 p77-87, 11p
Subject
Language
ISSN
10466673; 15333450
Abstract
Populations of Hispanic or Latino individuals have an increased risk of CKD, yet little is known about CKD genetics in these underserved groups. A genome-wide admixture mapping study of CKD traits conducted in 12,601 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) identified three novel ancestry-of-origin loci on African-derived and European-derived chromosomal haplotypes?implicating novel candidate genes for kidney function in these loci. Two of these loci were validated in Black individuals, indicating potential generalizability of the loci across populations with shared ancestry. Interestingly, a genome-wide association study in HCHS/SOL failed to identify these ancestry-specific regions. These results illustrate the utility of leveraging diverse ancestries viaadmixture mapping for new insights into the genetics of CKD traits in studies of recently admixed populations.