학술논문
Tristetraprolin-mediated hexokinase 2 expression regulation contributes to glycolysis in cancer cells
Document Type
Article
Author
Source
Molecular Biology of the Cell; March 2019, Vol. 30 Issue: 5 p542-553, 12p
Subject
Language
ISSN
10591524; 19394586
Abstract
Hexokinase 2 (HK2) catalyzes the first step of glycolysis and is up-regulated in cancer cells. The mechanism has not been fully elucidated. We demonstrate here that tristetraprolin (TTP) decreases HK2 expression and glycolysis by enhancing degradation of HK2 mRNA in cancer cells.