학술논문

Autophagy-assisted antigen cross-presentation
Document Type
Article
Source
OncoImmunology; September 2012, Vol. 1 Issue: 6 p976-978, 3p
Subject
Language
ISSN
21624011; 2162402X
Abstract
It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.