학술논문
Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation
Document Type
Article
Author
Source
Molecular Biology of the Cell; March 2019, Vol. 30 Issue: 5 p566-578, 13p
Subject
Language
ISSN
10591524; 19394586
Abstract
Activation of Yes-1 by mucosal cytokines during inflammation promotes tyrosine phosphorylation of JAM-A at Y280, destabilizing TJ-associated signaling elements, which results in decreased Rap2 GTPase activity and compromised epithelial barrier.