학술논문
Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing Syndrome.
Document Type
Article
Author
Source
The Journal of Clinical Endocrinology & Metabolism; November 2019, Vol. 104 Issue: 11 p5651-5657, 7p
Subject
Language
ISSN
0021972X; 19457197
Abstract
Prolonged adrenal stimulation by corticotropin, as in long-standing Cushing disease (CD), leads to diffuse to nodular hyperplasia. Adrenal functional autonomy has been described in a subset of patients with CD, leading to the hypothesis of transition from ACTH-dependent to ACTH-independent hypercortisolism.