학술논문
Evelynin, a Cytotoxic Benzoquinone-Type retro-Dihydrochalcone from Tacca chantrieri
Document Type
Article
Author
Source
Journal of Natural Products; September 2010, Vol. 73 Issue: 9 p1590-1592, 3p
Subject
Language
ISSN
01633864; 15206025
Abstract
A new benzoquinone-type retro-dihydrochalcone, named evelynin, was isolated from the roots and rhizomes of Tacca chantrieri.The structure was elucidated on the basis of the analysis of spectroscopic data and confirmed by a simple one-step total synthesis. Evelynin exhibited cytotoxicity against four human cancer cell lines, MDA-MB-435 melanoma, MDA-MB-231 breast, PC-3 prostate, and HeLa cervical carcinoma cells, with IC50values of 4.1, 3.9, 4.7, and 6.3 μM, respectively.