학술논문
A Novel Transcription Factor, zbtb11Is Critical for Neutrophil Development in Zebrafish
Document Type
Article
Source
Blood; November 2008, Vol. 112 Issue: 11 p284-284, 1p
Subject
Language
ISSN
00064971; 15280020
Abstract
Zinc finger and BTB domain containing proteins (BTB-ZF) are transcriptional repressors from a family including members with critical roles in hematopoiesis and oncogenesis (BCL6, PLZF, HIC). In an N-ethyl-N-nitrosourea (ENU) mutagenesis screen for defects in myeloid development, we identified a neutropenic zebrafish mutant with a mutation in zbtb11, a novel BTB-ZF transcription factor, suggesting that zbtb11is critical for normal neutrophil development.