학술논문
Catalytic Enantioselective Synthesis of (−)-Podophyllotoxin
Document Type
Article
Author
Source
Organic Letters; 20240101, Issue: Preprints
Subject
Language
ISSN
15237060; 15237052
Abstract
The first catalytic enantioselective total synthesis of (−)-podophyllotoxin is accomplished by a challenging organocatalytic cross-aldol Heck cyclization and distal stereocontrolled transfer hydrogenation in five steps from three aldehydes. Reversal of selectivity in hydrogenation led to the syntheses of other stereoisomers from the common precursor.