학술논문
Prediction of mortality benefit based on periodic repolarisation dynamics in patients undergoing prophylactic implantation of a defibrillator: a prospective, controlled, multicentre cohort study
Document Type
Article
Author
Bauer, Axel; Klemm, Mathias; Rizas, Konstantinos D; Hamm, Wolfgang; von Stülpnagel, Lukas; Dommasch, Michael; Steger, Alexander; Lubinski, Andrezej; Flevari, Panagiota; Harden, Markus; Friede, Tim; Kääb, Stefan; Merkely, Bela; Sticherling, Christian; Willems, Rik; Huikuri, Heikki; Malik, Marek; Schmidt, Georg; Zabel, Markus; Merkely, Béla; Perge, Peter; Sallo, Zoltan; Szeplaki, Gabor; Zabel, Markus; Lüthje, Lars; Schlögl, Simon; Haarmann, Helge; Bergau, Leonard; Seegers, Joachim; Hasenfuß, Gerd; Munoz-Exposito, Pascal; Tichelbäcker, Tobias; Kirova, Aleksandra; Friede, Tim; Harden, Markus; Malik, Marek; Hnatkova, Katerina; Vos, Marc; Willich, Stefan N.; Reinhold, Thomas; Willems, Rik; Vandenberk, Bert; Klinika, Magdalena; Toplice, Krapinske; Flevari, Panayota; Katsimardos, Andreas; Katsaras, Dimitrios; Hatala, Robert; Svetlosak, Martin; Lubinski, Andrzej; Kuczejko, Tomasz; Hansen, Jim; Sticherling, Christian; Conen, David; Milosrdnice, Sestre; Pavlović, Nikola; Manola, Šime; Vinter, Ozren; Benko, Ivica; Tuinenburg, Anton; Bauer, Axel; Meyer-Zürn, Christine; Eick, Christian; Hastrup, Jesper; Brugada, Josep; Arbelo, Elena; Kaliska, Gabriela; Martinek, Jozef; Dommasch, Michael; Steger, Alexander; Kääb, Stefan; Sinner, Moritz F.; Rizas, Konstantinos D.; Hamm, Wolfgang; Vdovin, Nikolay; Klemm, Mathias; von Stülpnagel, Lukas; Cygankiewicz, Iwona; Ptaszynski, Pawel; Kaczmarek, Krzysztof; Poddebska, Izabela; Iovev, Svetoslav; Novotný, Tomáš; Kozak, Milan; Huikuri, Heikki; Kenttä, Tuomas; Pelli, Ari; Kasprzak, Jaroslaw D.; Qavoq, Dariusz; Brusich, Sandro; Avdovic, Ervin; Klasan, Marina; Galuszka, Jan; Taborsky, Milos; Velchev, Vasil; Dissmann, Rüdiger; Guzik, Przemysław; Bimmel, Dieter; Lieberz, Christiane; Stefanow, Stefan; Rüb, Norman; Wolpert, Christian; Maier, Lars S.; Behrens, Steffen; Jurisic, Zrinka; Braunschweig, Frieder; Blaschke, Florian; Pieske, Burkert; Bakotic, Zoran; Anic, Ante; Schwinger, Robert H.G.; Platonov, Pyotr
Source
The Lancet; October 2019, Vol. 394 Issue: 10206 p1344-1351, 8p
Subject
Language
ISSN
01406736; 1474547X
Abstract
A small proportion of patients undergoing primary prophylactic implantation of implantable cardioverter defibrillators (ICDs) experiences malignant arrhythmias. We postulated that periodic repolarisation dynamics, a novel marker of sympathetic-activity-associated repolarisation instability, could be used to identify electrically vulnerable patients who would benefit from prophylactic implantation of ICDs by way of a reduction in mortality.