학술논문
Moderated Posters session: advanced echo techniques in congenital heart disease
Document Type
Article
Author
Haland, T; Almaas, VM; Hasselberg, NE; Saberniak, J; Leren, IS; Hopp, E; Edvardsen, T; Haugaa, KH; Neglia, L; Piazza, R; Doronzo, A; Leonelli, V; Morosin, M; Leiballi, E; Pecoraro, R; Lutman, C; Dragos, A; Cassin, M; Mas-Stachurska, A; Sitges, M; Meirelles, T; Hernandez, V; Egea, G; Bijnens, B; Malanin, D; Poggio, D; Ferrazzi, P; Spirito, P; Specchia, G; Grillo, M; Amigoni, P; Bersano, C; Pisani, M; Chioffi, M; Baruteau, A-E; Hascoet, S; Piot, D; Lambert, V; Petit, J; Pontnau, F; Ladouceur, M; Ferreira, A; Iserin, L; Mousseaux, E; Capotosto, L; D'angeli, I; Conde, Y; Ashurov, R; Miraldi, F; Vitarelli, A; Hristova, K; Dasheva, A; Marinov, R; Lasarov, S; Mitev, I; Mitev, P; Konstantinov, G; Kaneva, A; Katova, TZ; Sevilla, T; Revilla-Orodea, A; Uruena-Martinez, N; Fuertes-Alija, JJ; Rodriguez-Velasco, M; Gomez-Salvador, I; San Roman-Calvar, JA; Wojtkowska, A; Tomaszewski, A; Czekajska-Chehab, E; Wysokinski, A; Adamczyk, P; Siek, E; Zakoscielna, M
Source
European Journal of Echocardiography; December 2015, Vol. 16 Issue: Supplement 2 pS70-S70, 1p
Subject
Language
ISSN
15252167; 15322114
Abstract
Purpose: Myocardial fibrosis by cardiac magnetic resonance imaging (CMR) has been related to ventricular arrhythmias (VAs) in hypertrophic cardiomyopathy (HCM). We hypothesized that systolic function by strain echocardiography is related to VAs and to the extent of fibrosis by CMR. Methods: We studied 150 HCM patients (age 54 ± 14, 39% female). VAs were defined as ventricular tachycardia or aborted cardiac arrest. By speckle-tracking echocardiography we assessed global longitudinal strain (GLS) and mechanical dispersion defined as standard deviation of time from Q/R on ECG to peak negative longitudinal strain in 16 LV segments. Late gadolinium enhancement (LGE) was assessed by CMR and quantified as proportion of total LV myocardium (%LGE) Results: VAs were identified in 37 (25%) patients. Patients with VAs had worse GLS (-14.1 ± 3.6% vs. -16.3 ± 3.4%, p<0.01), more pronounced mechanical dispersion (79 ± 27 ms vs. 59 ± 16 ms, p<0.001), and higher %LGE (6.1 ± 7.8% vs. 0.5 ± 1.4%, p<0.001) than HCM patients without VAs (Figure). Mechanical dispersion was the only independent risk predictor of VAs (OR 1.6, 95%CI 1.1-2.3, p=0.02, per 10ms increase) in multivariate analysis. Mechanical dispersion correlated with %LGE (R= 0.52, p<0.001), and there was a weak, but significant correlation between GLS and % LGE (R=0.27, p=0.01), while neither EF (R=0.01, p=0.96) nor E/e’ (R=0.05, p=0.74) correlated with %LGE. Conclusion: Myocardial systolic function by strain echocardiography was related to VAs in HCM . Mechanical dispersion was a strong independent predictor of VAs and related to the extent of fibrosis on CMR and may improve risk stratification in HCM patients.