학술논문
Increased content of cells producing antibodies against syngeneic erythrocytes in the spleen of C57Bl/6 mice as a result of heterochronous parabiosis
Document Type
Article
Author
Source
Bulletin of Experimental Biology and Medicine; July 1996, Vol. 122 Issue: 1 p714-716, 3p
Subject
Language
ISSN
00074888; 15738221
Abstract
Abstract: The effect of lymphocyte exchange between young and old C57B1/6 mice in parabiotic pairs on the formation of autoreactive antibody-producing cells is studied during primary immune response. It is found that the content of cells producing antibodies against bromelain-treated murine erythrocytes after immunization with sheep erythrocytes is almost the same in young and old animals (as well as in the members of age-matching parabiotic pairs). However, parabiosis between young and old animals suppresses the immune response to sheep erythrocytes in young mice and stimulates the immune response to bromelain-treated murine erythrocytes both in young and old mice.