학술논문
Identification and haplotype analysis of LRRK2G2019S in Japanese patients with Parkinson disease
Document Type
Article
Author
Source
Neurology (Ovid); August 2006, Vol. 67 Issue: 4 p697-699, 3p
Subject
Language
ISSN
00283878; 1526632X
Abstract
LRRK2G2019S is the most common known cause of Parkinson disease (PD) in patients of European origin, but little is known about its distribution in other populations. The authors identified two of 586 Japanese patients with PD heterozygous for the mutation who shared a haplotype distinct from that observed in Europeans. This suggests that G2019S originated from separate founders in Europe and Japan and is more widely dispersed than previously recognized.