학술논문
The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation
Document Type
Article
Author
Source
Molecular Biology of the Cell; October 2015, Vol. 26 Issue: 19 p3424-3438, 15p
Subject
Language
ISSN
10591524; 19394586
Abstract
The nucleoporin ALADIN, which is mutated in patients with triple A syndrome, is necessary for proper spindle formation. Without ALADIN, active Aurora A moves away from centrosomes. The relocalization of active Aurora A leads to a redistribution of specific spindle assembly factors that make spindles less stable and slows their formation.