학술논문
Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials
Document Type
Article
Author
Gaudinski, Martin R; Houser, Katherine V; Morabito, Kaitlyn M; Hu, Zonghui; Yamshchikov, Galina; Rothwell, Ro Shauna; Berkowitz, Nina; Mendoza, Floreliz; Saunders, Jamie G; Novik, Laura; Hendel, Cynthia S; Holman, LaSonji A; Gordon, Ingelise J; Cox, Josephine H; Edupuganti, Srilatha; McArthur, Monica A; Rouphael, Nadine G; Lyke, Kirsten E; Cummings, Ginny E; Sitar, Sandra; Bailer, Robert T; Foreman, Bryant M; Burgomaster, Katherine; Pelc, Rebecca S; Gordon, David N; DeMaso, Christina R; Dowd, Kimberly A; Laurencot, Carolyn; Schwartz, Richard M; Mascola, John R; Graham, Barney S; Pierson, Theodore C; Ledgerwood, Julie E; Chen, Grace L; Plummer, Sarah; Costner, Pamela; Zephir, Kathryn; Casazza, Joseph; Ola, Abidemi; Victorino, Milalynn; Levinson, Carol; Whalen, William; Wang, Xiaolin; Cunningham, Jennifer; Vasilenko, Olga; Burgos Florez, Maria; Hickman, Somia; Pittman, Iris; Le, Lam; Larkin, Brenda; Andrews, Charla; Apte, Preeti; Hicks, Renunda; Trelles Cartagena, Cora; Williams, Pernell; Boyd, Catina R; Conan-Cibotti, Michelle; Stein, Judy; Kaltovich, Florence; DeCederfelt, Hope; McAdams, Stacey; Renehan, Phyllis; Chen, Wilbur; Greenberg, Nancy; Wymer, Nancy; Wadsworth, Linda; Billington, Melissa; Robinson, Toni; Boyce, Colleen; Pa'ahana Brown, Faith; Chrisley, Lisa; Kwon, Alyson; Patel, Prashant; Kominou, Panagoita; Dorsey, Brenda; Eddington, Staci; Telscher, Shinyi; Lee, Myoughee; Mosely, Regina; Ross, April; Ford, Geoffrey; Domjahn, Briyana; Xu, Jianguo; Beck, Allison; Fineman, Rebecca; Heeke, Shiela; Winter, Jean; Nagar, Shashi; Kelley, Colleen; Mulligan, Mark; Plummer, Sarah; Costner, Pamela; Zephir, Kathryn; Casazza, Joseph; Ola, Abidemi; Victorino, Milalynn; Levinson, Carol; Whalen, William; Wang, Xiaolin; Cunningham, Jennifer; Vasilenko, Olga; Burgos Florez, Maria; Hickman, Somia; Pittman, Iris; Le, Lam; Larkin, Brenda; Andrews, Charla; Apte, Preeti; Hicks, Renunda; Trelles Cartagena, Cora; Williams, Pernell; Boyd, Catina R; Conan-Cibotti, Michelle; Stein, Judy; Kaltovich, Florence; DeCederfelt, Hope; McAdams, Stacey; Renehan, Phyllis
Source
The Lancet; February 2018, Vol. 391 Issue: 10120 p552-562, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins.