학술논문
P2Y12Inhibitor Loading Time Before Elective PCI and the Prevention of Myocardial Necrosis
Document Type
Article
Author
Roule, Vincent; Beygui, Farzin; Cayla, Guillaume; Rangé, Grégoire; Motovska, Zuzana; Delarche, Nicolas; Jourda, François; Goube, Pascal; Guedeney, Paul; Zeitouni, Michel; El Kasty, Mohamad; Laredo, Mikael; Dumaine, Raphaëlle; Ducrocq, Gregory; Derimay, François; Van Belle, Eric; Manigold, Thibaut; Cador, Romain; Combaret, Nicolas; Vicaut, Eric; Montalescot, Gilles; Silvain, Johanne
Source
Canadian Journal of Cardiology; January 2024, Vol. 40 Issue: 1 p31-39, 9p
Subject
Language
ISSN
0828282X
Abstract
There are dated and conflicting data about the optimal timing of initiation of P2Y12inhibitors in elective percutaneous coronary intervention (PCI). Peri-PCI myocardial necrosis is associated with poor outcomes. We aimed to assess the impact of the P2Y12inhibitor loading time on periprocedural myocardial necrosis in the population of the randomized Assessment of Loading With the P2Y12Inhibitor Ticagrelor or Clopidogrel to Halt Ischemic Events in Patients Undergoing Elective Coronary Stenting (ALPHEUS) trial, which compared ticagrelor with clopidogrel in high-risk patients who received elective PCI.