학술논문
Italian Association of Hospital Cardiologists Position Paper ‘Gender discrepancy: time to implement gender-based clinical management’
Document Type
Article
Author
Lucà, Fabiana; Pavan, Daniela; Gulizia, Michele Massimo; Manes, Maria Teresa; Abrignani, Maurizio Giuseppe; Benedetto, Francesco Antonio; Bisceglia, Irma; Brigido, Silvana; Caldarola, Pasquale; Calvanese, Raimondo; Canale, Maria Laura; Caretta, Giorgio; Ceravolo, Roberto; Chieffo, Alaide; Chimenti, Cristina; Cornara, Stefano; Cutolo, Ada; Di Fusco, Stefania Angela; Di Matteo, Irene; Di Nora, Concetta; Fattirolli, Francesco; Favilli, Silvia; Francese, Giuseppina Maura; Gelsomino, Sandro; Geraci, Giovanna; Giubilato, Simona; Ingianni, Nadia; Iorio, Annamaria; Lanni, Francesca; Montalto, Andrea; Nardi, Federico; Navazio, Alessandro; Nesti, Martina; Parrini, Iris; Pilleri, Annarita; Pozzi, Andrea; Rao, Carmelo Massimiliano; Riccio, Carmine; Rossini, Roberta; Scicchitano, Pietro; Valente, Serafina; Zuccalà, Giuseppe; Gabrielli, Domenico; Grimaldi, Massimo; Colivicchi, Furio; Oliva, Fabrizio
Source
European Heart Journal Supplements: Journal of the European Society of Cardiology; April 2024, Vol. 26 Issue: 1, Number 1 Supplement 2 pii264-ii293, 30p
Subject
Language
ISSN
1520765X; 15542815
Abstract
It has been well assessed that women have been widely under-represented in cardiovascular clinical trials. Moreover, a significant discrepancy in pharmacological and interventional strategies has been reported. Therefore, poor outcomes and more significant mortality have been shown in many diseases. Pharmacokinetic and pharmacodynamic differences in drug metabolism have also been described so that effectiveness could be different according to sex. However, awareness about the gender gap remains too scarce. Consequently, gender-specific guidelines are lacking, and the need for a sex-specific approach has become more evident in the last few years. This paper aims to evaluate different therapeutic approaches to managing the most common women’s diseases.