학술논문
Abstract P258: The COVID-19 Pandemic is Not Associated With Worse 90-Day Functional Outcomes Following Endovascular Thrombectomy Despite Increased Delays to Recanalization
Document Type
Article
Author
Source
Stroke (Ovid); March 2021, Vol. 52 Issue: Supplement 1 pAP258-AP258, 1p
Subject
Language
ISSN
00392499; 15244628
Abstract
Introduction:Several comprehensive stroke centers (CSC) have reported increased delays to reperfusion in acute stroke during the COVID-19 pandemic, but it is unknown whether the pandemic is associated with worse functional outcomes in EVT-treated patients.Methods:We performed an observational cohort study of consecutive adult patients evaluated for suspected stroke at our CSC (located in Montreal, a Canadian pandemic epicenter) between March 30 and May 15 2020 (prospective pandemic cohort) and 2019 (retrospective non-pandemic cohort). We excluded in-hospital strokes. We compared short-term (in-house door-to-puncture and door-to-recanalization delays, TICI 2b/3, complications during EVT) and long-term (90-day mRS ≤2 and death) outcomes with univariate analyses. We assessed the effect of the pandemic on 90-day mRS while controlling for clinical confounders.Results:Overall, 111 and 106 patients were included in the pandemic and non-pandemic cohorts, respectively. The prevalence of COVID-19 in the pandemic cohort was 3% (3/104). Among ischemic stroke patients, 31/77 (40%) and 41/71 (58%) underwent EVT in each respective cohort (p=0.03). Among EVT-treated patients, baseline characteristics and NIHSS scores were similar (median [interquartile range]: 20 [12-25] vs 18 [14-20], p=0.18), but pre-stroke mRS was lower in the exposed cohort (0 [0-1] vs 1 [0-2], p=0.04). Door-to-puncture (87 [65-102] vs 56 [47-74] min, p=0.07) metrics were similar, but door-to-recanalization (122 [99-126] vs 89 [67-97] min, p<0.01) metrics were longer during the pandemic. The proportions of patients with TICI 2b/3 (94 vs 85%, p=0.27) and with complications during EVT (23 vs 22%, p=0.95) were similar, as were those for 90-day mRS ≤2 (42 vs 37%, p=0.64) and death (19 vs 20%, p=0.99). The logistic multivariate regression did not disclose an association between the COVID-19 pandemic and 90-day mRS ≤2 (aOR 0.70, 95% CI 0.06-7.95).Conclusion:The COVID-19 pandemic does not appear to have a negative impact on 90-day functional status among EVT-treated patients despite increased delays to recanalization. However, patient selection may have been stricter during the pandemic, as a smaller proportion of evaluated patients underwent EVT and those treated had lower pre-stroke mRS.