학술논문
Cerebellar Syndrome Caused by Isoniazid
Document Type
Article
Author
Source
The Annals of Pharmacotherapy; September 1990, Vol. 24 Issue: 9 p829-831, 3p
Subject
Language
ISSN
10600280; 15426270
Abstract
Treatment of tuberculosis in a hemodialysis patient with isoniazid, rifampin pyrazinamide resulted in the development of acute cerebellar dysfunction. This resolved rapidly following the discontinuation of isoniazid and pyrazinamide, reinstitution of isoniazid at a lower dose addition of pyridoxine. We discuss why we believe this syndrome was caused by isoniazid. Patients with renal failure who undergo antituberculous therapy with isoniazid should receive supplemental pyridoxine to reduce the likelihood of isoniazid-related neurotoxicity.