학술논문
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation
Document Type
Article
Author
Source
Genes & Development; 2023, Vol. 37 Issue: 5-6 p218-242, 25p
Subject
Language
ISSN
08909369; 15495477
Abstract
In this study, Păun et al. describe how pioneer transcription factor ASCL1 regulates activation of gene regulatory elements involved in neuronal differentiation. They also show that ASCL1 interacts with the ATPase-dependent mSWI/SNF complex, elucidating a new mechanism of chromatin remodeling in human neurogenesis.