학술논문
Nucleosome structure and dynamics are coming of age
Document Type
Article
Author
Source
Nature Structural and Molecular Biology; January 2019, Vol. 26 Issue: 1 p3-13, 11p
Subject
Language
ISSN
15459993; 15459985
Abstract
Since the first high-resolution structure of the nucleosome was reported in 1997, the available information on chromatin structure has increased very rapidly. Here, we review insights derived from cutting-edge biophysical and structural approaches applied to the study of nucleosome dynamics and nucleosome-binding factors, with a focus on the experimental advances driving the research. In addition, we highlight emerging challenges in nucleosome structural biology.