학술논문
Falls Predict Acute Hospitalization in Parkinson’s Disease
Document Type
Article
Author
Santos García, Diego; de Deus Fonticoba, Teresa; Cores, Carlos; Suárez Castro, Ester; Hernández Vara, Jorge; Jesús, Silvia; Mir, Pablo; Cosgaya, Marina; José Martí, Maria; Pastor, Pau; Cabo, Iria; Seijo, Manuel; Legarda, Inés; Vives, Bárbara; Caballol, Nuria; Rúiz Martínez, Javier; Croitoru, Ioana; Cubo, Esther; Miranda, Javier; Alonso Losada, Maria Gema; Labandeira, Carmen; López Ariztegui, Nuria; Morales-Casado, Mabel; González Aramburu, Isabel; Infante, Jon; Escalante, Sonia; Bernardo, Noemí; Blázquez Estrada, Marta; Menéndez González, Manuel; García Caldentey, Juan; Borrué, Carmen; Vela, Lydia; Catalán, Maria José; Gómez Mayordomo, Víctor; Kurtis, Mónica; Prieto, Cristina; Ordás, Carlos; Nogueira, Víctor; López Manzanares, Lydia; Ávila Rivera, Maria Asunción; Puente, Victor; García Moreno, Jose Manuel; Solano Vila, Berta; Álvarez Sauco, María; Carrillo Padilla, Francisco; Martínez Castrillo, Juan Carlos; Sánchez Alonso, Pilar; Gastón, Itziar; Kulisevsky, Jaime; Valero, Caridad; de Fábregues, Oriol; González Ardura, Jessica; López Díaz, Luis Manuel; Martinez-Martin, Pablo
Source
Journal of Parkinson's Disease; January 2023, Vol. 13 Issue: 1 p105-124, 20p
Subject
Language
ISSN
18777171; 1877718x
Abstract
There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. Thirty-five out of 605 (5.8%) PD patients (62.5±8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065–5.678; p= 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319–6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757–8.470; p= 0.001), and dysphagia (HR 2.356; 95% CI 1.124–4.941; p= 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080–8.322; p= 0.035) was an independent predictor of AH. Falls is an independent predictor of AH in PD patients.