학술논문
Factors influencing dabigatran or warfarin medication persistence in patients with nonvalvular atrial fibrillation
Document Type
Article
Author
Source
Journal of Comparative Effectiveness Research; July 2018, Vol. 7 Issue: 7 p685-691, 7p
Subject
Language
ISSN
20426305; 20426313
Abstract
Factors influencing differences in persistence between dabigatran and warfarin in patients with nonvalvular atrial fibrillation (NVAF) remain unclear. Aim:Compare differences in persistence between new dabigatran and warfarin users in patients newly diagnosed with NVAF, adjusting for sociodemographics, clinical characteristics, patient out-of-pocket cost and other covariates. Methods:A retrospective matched-cohort study was conducted using a US claims database of Medicare and commercially insured patients with NVAF aged≥ 18 years. Persistence and monthly out-of-pocket costs for dabigatran or warfarin were calculated and adjusted for covariates using Cox proportional hazard models. Results & conclusion:Unadjusted persistence was significantly lower among dabigatran users (n 1025) compared with matched warfarin users (38 vs 46). Adjusting for covariates rendered this difference insignificant (hazard ratio 0.930).