학술논문
NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation
Document Type
Article
Author
Huth, Michelle; Santini, Laura; Galimberti, Elena; Ramesmayer, Julia; Titz-Teixeira, Fabian; Sehlke, Robert; Oberhuemer, Michael; Stummer, Sarah; Herzog, Veronika; Garmhausen, Marius; Romeike, Merrit; Chugunova, Anastasia; Leesch, Friederike; Holcik, Laurenz; Weipoltshammer, Klara; Lackner, Andreas; Schoefer, Christian; von Haeseler, Arndt; Buecker, Christa; Pauli, Andrea; Ameres, Stefan L.; Smith, Austin; Beyer, Andreas; Leeb, Martin
Source
Genes & Development; 2022, Vol. 36 Issue: 5-6 p348-367, 20p
Subject
Language
ISSN
08909369; 15495477
Abstract
Here, Huth et al. investigated the role of components of the nonsense-mediated mRNA decay (NMD) pathway in regulating embryonic stem cell (ESC) differentiation, and show that NMD controls expression levels of the translation initiation factor Eif4a2and its premature termination codon-encoding isoform (Eif4a2PTC). Their findings expose an intricate link between mRNA homeostasis and mTORC1 activity that must be maintained for normal dynamics of cell state transitions.