학술논문
HIT Poster session 2
Document Type
Article
Author
Bucciarelli, V; Bianco, F; Izzicupo, P; Ghinassi, B; Di Baldassarre, A; Gallina, S; Avenatti, E; Milazzo, V; Milan, A; Patel, A; Kuvin, J; Pandian, N; Rosner, SJ; Orban, M; Nadjiri, J; Lesevic, H; Hadamitzky, M; Sonne, C; Cherneva, ZHCH; Kuneva, ZK; Vasilev, DV; Li, H; Yuan, L; Xie, MX; Jin, XY; Surkova, E A; Muraru, D; Grapsa, J; Donal, E; Lancellotti, P; Habib, G; Badano, L P; Degiovanni, A; Buffa, MC; De Vecchi, F; Prenna, E; Boggio, E; Marino, P; Ortiz Garrido, A; De La Chica, J; Cuenca Peiro, V; Picazo Angelin, B; Conejo Munoz, L; Narbona, I; Anderica, JR; De Mora, M; Zabala Arguelles, JI; Mihaila, S; Velcea, A; Matei, L; Andronic, A; Calin, S; Rimbas, R; Muraru, D; Badano, LP; Vinereanu, D; Tamulenaite, E; Ovsianas, J; Valuckiene, Z; Jurkevicius, R; Amorouayeche, F Z; Latreche, S; Benkhedda, S; Kolesnyk, M Y; Dzyak, G V; Riznyk, Y Y; Kovalyova, O V; Garcia Campos, A; Velasco-Alonso, E; Colunga-Blanco, S; Martin-Fernandez, M; Corros-Vicente, C; Rodriguez-Suarez, ML; Leon-Aguero, V; De La Hera Galarza, JM; Savcioglu, AS; Safak, O; Nazli, C; Akyildiz Akcay, F; Yakar Tuluce, S; Kahya Eren, N; Ozdemir, E; Kocabas, U; Filipiak, D; Kasprzak, JD; Lipiec, P; Kuusisto, J K; Jarvinen, VM; Sinisalo, JP; Torbas, O; Sirenko, YU; Radchenko, G; Rekovets, O; Kushnir, S; Kupczynska, K; Michalski, BW; Miskowiec, D; Kasprzak, JD; Wdowiak-Okrojek, K; Wejner-Mik, P; Lipiec, P; Tountas, X; Beldekos, D; Protogerou, A; Gournizakis, A; Panopoulos, S; Theodosis-Georgilas, A; Fousas, S; Sfikakis, P; Ionin, VA; Soboleva, AV; Listopad, OV; Nifontov, SE; Polyakova, EA; Belyaeva, OD; Baranova, EI; Shlyachto, EV; Cescau, A; Baudet, M; Cohen-Solal, A; Logeart, D; Altin, C; Sakallioglu, O; Aydin, E; Yilmaz, M; Sade, LE; Muderrisoglu, H; Ferreiro Quero, C; Mesa Rubio, M D; Ruiz Ortiz, M; Delgado Ortega, M; Sanchez Fernandez, J; Duran Jimenez, E; Morenate Navio, C; Romero, M; Pan, M; Suarez De Lezo, J; Lowery, C; Frenneaux, M P; Parasuraman, S K; Rudd, A E; Srinivasan, J; Najih, H; Elbaghdadi, D; Laarej, A; Allouch, M; Azzouzi, L; Habbal, R; Valuckiene, Z; Ovsianas, J; Mizariene, V; Ablonskyte-Dudoniene, R; Jurkevicius, R; Onciul, S; Cucchini, U; Miglioranza, MH; Dorobantu, M; Iliceto, S; Badano, LP; Muraru, D; Yang, L-T; Tsai, WC; Baricevic, Z; Cikes, M; Ljubas Macek, J; Skoric, B; Skorak, I; Jurin, H; Samardzic, J; Gasparovic, H; Milicic, D; Separovic Hanzevacki, J; Ghulam Ali, S; Fusini, L; Tamborini, G; Gripari, P; Muratori, M; Celeste, F; Carminati, MC; Alamanni, F; Pepi, M
Source
European Journal of Echocardiography; December 2015, Vol. 16 Issue: Supplement 2 pS59-S59, 1p
Subject
Language
ISSN
15252167; 15322114
Abstract
Background: Menopause is associated with worsening of cardiovascular (CV) risk factors that can be counteract by physical exercise. Between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, the deletion variant (DD) is related to higher levels of circulating angiotensin II. We evaluated the effect of a short term endurance exercise program on CV remodeling, by means of 2-D echocardiography, among healthy, sedentary, postmenopausal women with ACE I/D genotypes. Methods: Fifty-three women (mean age 56 ± 4 years) underwent a 4 months moderate intensity walking training, eliciting an effort equal to 11-12 according the rating of perceived exertion scale (RPE). Partecipants' attendance at physical exercise program was 85.90 ± 10.75%. The ACE genotype was ascertained by polimerase chain reaction (DD in 20; ID in 27) before (T0) and after training (T1), along with laboratory, anthropometric and echocardiographic measurements. Results: We observed in both groups a significant reduction in systolic and diastolic blood pressure, weight and body mass index, along with a significant increase in left ventricular ejection fraction and diastolic function. Only ID group showed a significant decrease in heart rate and relative wall thickness [RWT ± SD] (T0 0.42 ± 0.06 – T1 0.40 ± 0.05, P 0.04), with a significant increase in left ventricular mass index [LVMI, g/m(2.7) ± SD] (T0 44.58 ± 11.28 – T1 47.34 ± 9.94, P 0.004) and in right ventricular systolic function, assessed by tricuspid annular plane systolic excursion [TAPSE, mm ± SD] (T0 22.52 ± 0.3 – T1 22.96 ± 0.3, P 0.03). Conclusions: Short term aerobic exercise program ameliorates CV profile in healthy, sedentary, postmenopausal women and is associated with positive left ventricular remodeling in ID patients. Enhanced ACE activity, as in DD genotype, could reduce this phenomenon. Thus, ACE polymorphism could account for the individual cardiac remodeling response to physical exercise and should be considered in order to optimize CV prevention measures.