학술논문
Prospective multi-center validation of the detection of ALKrearrangements of circulating tumor cells for non-invasive longitudinal management of patients with advanced non-small cell lung cancer
Document Type
Article
Author
ILIE, Marius; MAZIÈRES, Julien; CHAMOREY, Emmanuel; HEEKE, Simon; BENZAQUEN, Jonathan; THAMPHYA, Brice; BOUTROS, Jacques; TIOTIU, Angelica; FAYADA, Julien; CADRANEL, Jacques; POUDENX, Michel; MORO-SIBILOT, Denis; BARLESI, Fabrice; THARIAT, Juliette; CLEMENT-DUCHENE, Christelle; TOMASINI, Pascale; HOFMAN, Véronique; MARQUETTE, Charles-Hugo; HOFMAN, Paul; ISRAEL-BIET, Dominique; PISON, Christophe; MORO-SIBILOT, Denis; LANTUEJOUL, Sylvie; STEPHANOV, Olivier; Juliette, M.E.Y.Z.E.N.C.; MENDOZAT, Christophe; ZAIDI, Manel; COULOUVRAT, Sandra; COL, Edwige; CHANEZ, Pascal; GREILLIER, Laurent; TOMASINI, Pascale; BARLESI, Fabrice; MASCAUX, Céline; JOURDAN, Sandrine; ROGER, Aurélie; BIEMAR, Julie; RANDRIAMAMPIONONA, Rondro; CHABOT, François; TIOTIU, Angélica; CLEMENT-DUCHENE, Christelle; Jean-Michel, V.I.G.N.A.U.D.; LACOMME, Stéphanie; LOMAZZI, Sandra; LAURENT, Carine; BULSEI, Xavier; BISCHOFF, Laura; RAKOTONIRINA, Raymond; LAYOUNI, Mehdi; DESLEE, Gaëtan; MAL, Hervé; KESSLER, Romain; VERGNON, Jean-Michel; PELISSIER, Isabelle; CUVELIER, Antoine; BOURDIN, Arnaud; JOUNIEAUX, Vincent; ROCHE, Nicolas; JOUNEAU, Stéphane; BONNIAUD; SCHERPEREEL, Arnaud; MORNEX, Jean François; STEENHOUWER, François; LEROY, Sylvie; MARQUETTE, Charles Hugo; BENZAQUEN, Jonathan; MAZZETTE, Andrea; PADOVANI, Bernard; HOFMAN, Paul; ILIE, Marius; HOFMAN, Véronique; FAYADA, Julien; LONG-MIRA, Elodie; LASSALLE, Sandra; PRADELLI, Johanna; MARTINEZ, Estelle; HABAULT, Marine; BONNARD, Mélanie; MOUTARDE, Julie; YATIMI, Rachida; LABSI, Hakima; GAZOPPI, Loïc; LPCE, Tumorothèque; GRIFFONNET, Jennifer; FONTAINE, Maureen; GUILLEMART, Ariane; BUTORI, Catherine; SELVA, Eric; POUDENX, Michel; OTTO, Josiane; HEBERT, Christophe; BOTCHIELLINI, Delphine; BOUDOUF, Soukaina; MENIER, Margaux; OCCELI, Estelle; BELLENTANI, Sophie; PION, Carine; FOURNIER, Elodie; THARIAT, Juliette; GERVAIS, Radj; HAMOND, Karim; MARCHAND-ADAM, Sylvain; PLANTIER, Laurent; FAJOLLE, Gaelle; RAYEZ, Mélanie; CADRANEL, Jacques; FALLET, Vincent; WISLEZ, Marie; ANTOINE, Martine; COTE, Jean-François; CHAABANE, Nouha; RUPPERT, Anne Marsie; BERTRAND, Eliane; RODENAS, Anita; PONTDEME, Gwenaëlle; MATHIOT, Nathalie; RIBERT, Tamazouzt; MAZIÈRES, Julien; GUIBERT, Nicolas; ROUVIERE, Damien; BOUSQUET, Emilie; BIGAY-GAME, Laurence; HERMANT, Christophe; PLAT, Gavin; ROUQUETTE, Isabelle; EVRARD, Solène; GOUIN, Sandrine; TARANCHON CLERMONT, Estelle; DORMOY, Inge; COULOMB, Christelle; PRADINE, Anne; LAMBERT, Véronique; LABORDE, Lilian; CASTELNAU, Olivier
Source
Journal of Thoracic Oncology; 20210101, Issue: Preprints
Subject
Language
ISSN
15560864; 15561380
Abstract
Patients with advanced-stage non-small cell lung cancer (NSCLC) whose tumors harbor an anaplastic lymphoma kinase (ALK) gene rearrangement benefit from treatment with multiple ALK inhibitors (ALKi). Approximately 30% of tumor biopsies contain insufficient tissue for successful ALKmolecular characterization. This study evaluated the added value of analyzing circulating tumor cells (CTCs) as a surrogate to ALKtissue analysis and as a function of the response to ALKi.