학술논문
Characterization of Comparative Clinical Outcomes and Molecular Features of Black Patients with Acute Promyelocytic Leukemia (APL) Reveals Similar Survival and Distinct Genomic Profiles
Document Type
Article
Author
Habib, Alma; Boateng, Isaiah; Nicolet, Deedra; Mrózek, Krzysztof; Fisher, James L; Waller, Allyson; Stiff, Andrew; Buss, Jill; Laganson, Andrea; Martinez Corzine, Sienna; Hamp, Ethan; Abu-Shihab, Yazan; Powell, Bayard L; Uy, Geoffrey L; Stock, Wendy; Stone, Richard M; Kolitz, Jonathan E; Wang, Eunice S.; Carroll, Andrew J; Tyner, Jeffrey W; Hantel, Andrew; Paskett, Electra D; Byrd, John C.; Mardis, Elaine R; Plascak, Jesse J; Eisfeld, Ann-Kathrin
Source
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p389-389, 1p
Subject
Language
ISSN
00064971; 15280020
Abstract
Introduction:Although APL, a subtype of acute myeloid leukemia (AML), is an aggressive disease, its treatment was revolutionized with combination all- transretinoic acid (ATRA) and arsenic trioxide (ATO), making APL a highly curable malignancy. Molecularly, APL is characterized by t(15;17) resulting in PML:: RARAgene fusion as disease-initiating event and by several recurrent gene mutations (eg, FLT3) identified in previous studies. In AML, prior studies have established inferior overall survival (OS) of Black versus White AML patients (pts) in both population-based analyses and clinical trials, found a negative prognostic impact of higher social deprivation (SDI), and characterized differences in frequencies and impact of disease-associated gene mutations. Herein, we compared OS of Black and White APL pts and evaluated genomic landscape of Black pts, which has not been comprehensively assessed to date.