학술논문
CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XLinhibition by navitoclax and DT2216
Document Type
Article
Author
Gress, Verena; Roussy, Mathieu; Boulianne, Luc; Bilodeau, Mélanie; Cardin, Sophie; El-Hachem, Nehme; Lisi, Véronique; Khakipoor, Banafsheh; Rouette, Alexandre; Farah, Azer; Théret, Louis; Aubert, Léo; Fatima, Furat; Audemard, Éric; Thibault, Pierre; Bonneil, Éric; Chagraoui, Jalila; Laramée, Louise; Gendron, Patrick; Jouan, Loubna; Jammali, Safa; Paré, Bastien; Simpson, Shawn M.; Tran, Thai Hoa; Duval, Michel; Teira, Pierre; Bittencourt, Henrique; Santiago, Raoul; Barabé, Frédéric; Sauvageau, Guy; Smith, Martin A.; Hébert, Josée; Roux, Philippe P.; Gruber, Tanja A.; Lavallée, Vincent-Philippe; Wilhelm, Brian T.; Cellot, Sonia
Source
Blood Advances; January 2024, Vol. 8 Issue: 1 p112-129, 18p
Subject
Language
ISSN
24739529; 24739537
Abstract
•Cord blood–derived CBFA2T3::GLIS2 high-fidelity AMKL models contribute to capture the cellular and molecular heterogeneity of the disease.•BCL-XLinhibition is revealed as a therapeutic vulnerability in CG2 and NUP98r AMKL.