학술논문
Doravirine versus ritonavir-boosted darunavir in antiretroviral-naive adults with HIV-1 (DRIVE-FORWARD): 96-week results of a randomised, double-blind, non-inferiority, phase 3 trial
Document Type
Article
Author
Molina, Jean-Michel; Squires, Kathleen; Sax, Paul E; Cahn, Pedro; Lombaard, Johan; DeJesus, Edwin; Lai, Ming-Tain; Rodgers, Anthony; Lupinacci, Lisa; Kumar, Sushma; Sklar, Peter; Hanna, George J; Hwang, Carey; Martin, Elizabeth Anne; Hagins, Debbie P.; Osiyemi, Olayemi O.; Prelutsky, David James; Ramgopal, Moti N.; Scarsella, Anthony John; Dretler, Robin; DeJesus, Edwin; Bettacchi, Christopher J.; Sims, James; Clay, Patrick G.; Bellos, Nicholaos C.; Thompson, Melanie A.; Montero, Jose; McDonald, Cheryl K.; Creticos, Catherine; Shamblaw, David; Mogyoros, Miguel; Terrelonge, Antonio E.; Valdes, Martin; Tashima, Karen T.; Robbins, William J.; Felizarta, Franco Antonio; Elion, Richard A.; Slim, Jihad; Win, Sandra S.; Lalla-Reddy, Sujata N.; Ruane, Peter Jerome; Mills, Anthony; Cade, Jerry L.; Dietz, Craig A.; Rubin, David Scott; Mayer, Cynthia; Rondon, Juan Carlos; Cook, Paul P.; Daar, Eric; Kumar, Princy N.; Swindells, Susan; Castro, Jose Guillermo; Melendez-Rivera, Ivan; Morales-Ramirez, Javier O.; Santiago, Lizette; Santana-Bagur, Jorge L.; Martins, Marcelo; Cahn, Pedro Enrique; Lopardo, Gustavo D.; Porteiro, Norma; Bloch, Mark Theo; Baker, David Alfred; Roth, Norman; Moore, Richard James; Finlayson, Robert James; McMahon, James; Rieger, Armin; Zoufaly, Alexander; Hartl, Sylvia; Zangerle, Robert; Smaill, Fiona; Walmsley, Sharon L.; Conway, Brian; Rachlis, Anita; Smith, Graham H.R.; Perez, Carlos; Afani, Alejandro; Campos, Maria Isabel; Chahin, Carolina Eugenia; Wolff Reyes, Marcelo; Gerstoft, Jan; Weis, Nina; Laursen, Alex Lund; Molina, Jean-Michel; Yazdanpanah, Yazdan; Cotte, Laurent; Raffi, Francois; Morlat, Philippe; Girard, Pierre-Marie; Katlama, Christine; Rockstroh, Juergen K.; Arasteh, Keikawus; Esser, Stefan; Stoehr, Albrecht; Stellbrink, Hans-Juergen; Stoll, Matthias; Schuermann, Dirk; Faetkenheuer, Gerd; Bogner, Johannes; Lutz, Thomas; Baumgarten, Axel; Jaeger, Hans; Gori, Andrea; Coltan, Gabriel; Constandis, Felicia; Erscoiu, Simona Manuela; Prisacariu, Liviu-Jany; Rugina, Sorin; Streinu-Cercel, Adrian; Pokrovsky, Vadim Valentinovich; Zakharova, Natalia V.; Shuldyakov, Andrey Anatolyevich; Ryamova, Elena Pavlovna; Kulagin, Valeriy Viktorovich; Tsybakova, Olga Aleksandrovna; Orlova-Morozova, Elena; Nagimova, Firaya; Voronin, Evgeniy; Shimonova, Tatyana Evgenyevna; Kozyrev, Oleg Anatolyevich; Orrell, Catherine; Lombaard, Johannes Jurgens; de Jager, Marleen; Portilla Segorb, Joaquin; Mallolas, Josep; Perez Elias, Maria Jesus; Gatell, Josep M.; Arribas Lopez, Jose Ramon; Negredo Puigmal, Eugenia; Podzamczer Palter, Daniel; Pulido Ortega, Federico; Troya Garcia, Jesus; De los Santos Gil, Ignacio; Berenguer Berenguer, Juan; Williams, Ian G.; Johnson, Margaret A.; Schembri, Gabriel; Clarke, Amanda; Gompels, Mark; Fox, Julie Meriel; Taylor, Steven John; Dockrell, David Harold; Kegg, Stephen
Source
The Lancet HIV; January 2020, Vol. 7 Issue: 1 pe16-e26, 11p
Subject
Language
ISSN
24054704; 23523018
Abstract
Doravirine is a novel, non-nucleoside reverse transcriptase inhibitor that has shown non-inferior efficacy to ritonavir-boosted darunavir, with a superior lipid profile, in adults with HIV who were treatment naive at week 48 in the phase 3 DRIVE-FORWARD trial. Here we present the 96-week data for the study.