학술논문
Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study
Document Type
Article
Author
Piccini, Jonathan P; Caso, Valeria; Connolly, Stuart J; Fox, Keith A A; Oldgren, Jonas; Jones, W Schuyler; Gorog, Diana A; Durdil, Václav; Viethen, Thomas; Neumann, Christoph; Mundl, Hardi; Patel, Manesh R; Auer, Johann; Hubauer, Martin; Pandzic, Sead; Preishuber, Eva; Primus-Grabscheit, Carina; Reitgruber, Dietmar; Schmalzer, Florian; Adlbrecht, Christopher; Schober, Andreas; Hajos, Johannes; Keil, Christoph; Schratter, Alexandra; Frick, Matthias; Benda, Magdalena Anna; Mächler, Maximilian; Mutschlechner, Beatrix; Saely, Christoph; Sprenger, Lukas; Lichtenauer, Michael; Eber, Miriam; Hoppe, Uta; Kolbitsch, Tobias; Jirak, Peter Michael; Mirna, Moritz; Schönbauer, Robert; Bergler-Klein, Jutta; Hengstenberg, Christian; Stojkovic, Stefan; Scherr, Daniel; Manninger-Wünscher, Martin; Rohrer, Ursula; Stühlinger, Markus; Schgoer, Wilfried; Schwarzl, Jana; Pürerfellner, Helmut; Derndorfer, Michael; Ebner, Christian; Eder, Veronika; Kollias, Georgios; Sturmberger, Thomas; Sieghartsleitner, Stefan; Vijgen, Johan; Koopman, Peter; Dujardin, Karl; Anné, Wim; De Ceuninck, Michel; Tavernier, Rene; Duytschaever, Mattias; Knecht, Sébastien; Missault, Luc; Vandekerckhove, Yves; Rossenbacker, Tom; Ector, Bavo; Charlier, Filip; Debruyne, Philippe; Dewilde, Willem; Janssens, Luc; Roosen, John; Vankelecom, Bart; Heidbuchel, Hein; Delesie, Michiel; Vervoort, Gert; Rombouts, Hans; Vanassche, Thomas; Engelen, Matthias; Verhamme, Peter; Willems, Rik; Constance, Christian; Pranno, Nicolas; Cox, Jafna; Bata, Iqbal; Macle, Laurent; Aguilar, Martin; Tourigny, Julia Cadrin; Dubuc, Marc; Dyrda, Katia; Guerra, Peter; Khairy, Paul; Mondésert, Blandine; Rivard, Léna; Roy, Denis; Tadros, Rafik; Talajic, Mario; Thibault, Bernard; Nault, Isabelle; Blier, Louis; Champagne, Jean; Molin, Franck; O'Hara, Gilles; Philippon, François; Plourde, Benoit; Sarrazin, Jean-François; Steinberg, Christian; Coufal, Zdenek; Balazsik, David; Mikulica, Michal; Zapeca, Jakub; Cermak, Ondrej; Drasnar, Tomas; Falc, Matej; Hornof, Josef; Racz, Blazej; Weissova, Danica; Linkova, Hana; Paskova, Eva; Petr, Robert; Sirakova, Andrea; Kettner, Jiri; Benak, Ales; Holek, Martin; Podpera, Ivo; Podperova, Monika; Vancura, Vlastimil; Jandik, Tomas; Smid, Jiri; Dedek, Vratislav; Banik, Jan; Durdil, Vaclav; Hnat, Tomas; Lellouche, Nicolas; Rouffiac, Ségolène; Taldir, Guillaume; Bridonneau, Valentin; Couffon, Philippe; Daudin, Magalie; Hamon, Cécile; Lacaze, Jonathan; Quentin, Anne; Thebault, Christophe; Boiffard, Emmanuel; Billon, Olivier; Miette, Fabien; Pouliquen, Hervé; Turlotte, Guillaume; Gorka, Hervé; Albert, Franck; Bayle, Sandrine; Bensaid, Reda; Dasoveanu, Madalina; Demichili, Thibaud; Dutoiu, Teodora; Khalil, Cliff; Loghin, Caterina; Range, Grégoire; Roussel, Laurent; Socié, Pierre; Thuaire, Christophe; Extramiana, Fabrice; Algalarrondo, Vincent; Boughanmi, Haten; El Mansour, Noreddine; Mohammad, Usman; Sellier, Romain; Elbaz, Meyer; Laperche, Clémence; Maury, Philippe; Kiss, Robert; Borsanyi, Tunde; Gingl, Zoltan; Polgar, Balaza; Benczur, Bela; Bodor, Alexandra; Hepp, Tamas; Malati, Eva; Nagy, Laszlo; Erdei, Norbert; Kapus, Jozsef; Kapus, Katalin; Toth, Brigitta; Matoltsy, Andras; Kiss, Tunde; Merkely, Bela; Herczeg, Szilvia; Kiss, Orsolya; Sallo, Zoltan; Toth, Kalman; Habon, Tamas; Rabai, Miklos; Totsimon, Kinga; Zilahi, Zsolt; Bencze, Gabriella; Santa, Janos; Aradi, Daniel; Kelemen, Barbara; Bolognese, Leonardo; Nesti, Martina; Notarstefano, Pasquale Giovanni; D'Orazio, Simona; Cosmi, Franco; Becattini, Cecilia; Agnelli, Giancarlo; Broccatelli, Belinda; Mosconi, Maria Giulia; Paciaroni, Maurizio; Urbini, Chiara; Parato, Vito Maurizio; Notaristefani, Camilla; Scarano, Michele; Ameri, Pietro; Ghigliotti, Giorgio; Guglielmi, Giulia; Lotti, Roberta; Merlo, Andrea Carlo; Muiesan, Maria Lorenza; Abondio, Andrea; Berasi, Caterina; Mattiuzzo, Elena; Mutti, Claudio; Salvetti, Massimo; Pignatelli, Pasquale; Menichelli, Danilo; Pastori, Daniele; Tamiya, Eiji; Matsumoto, Takahiro; Takabe, Tomosato; Yamamoto, Shoichi; Yamashita, Haruyo; Higashiue, Shinichi; Furuya, Onichi; Hiramatsu, Norihiko; Kasuga, Kensuke; Kojima, Saburo; Komooka, Masatoshi; Kuroyanagi, Satoshi; Matsuura, Makoto; Takemoto, Tetsushi; Yamamoto, Shuji; Saito, Katusmi; Abe, Takuro; Ishida, Issei; Iwanami, Yuji; Kataoka, Shohei; Moriyama, Tetsu; Murohashi, Akira; Sasaki, Akihito; Nakamura, Yuichiro; Ueno, Tetsuya; Shimane, Akira; Hamana, Tomoyo; Ichibori, Hirotoshi; Inoue, Tomohiro; Itoh, Mitsuaki; Iwane, Seigo; Kawai, Hiroya; Kokawa, Tatsuya; Masumoto, Akiko; Matsuo, Koki; Miyata, Taishi; Nakano, Shinsuke; Oishi, Shogo; Onishi, Tetsuari; Sawada, Takahiro; Saito, Takayuki; Shoda, Mitsuhiko; Takahashi, Nobuyuki; Takaya, Tomofumi; Taniguchi, Yasuyo; Tsukamoto, Shota; Tsukishiro, Yasue; Tsukiyama, Yoshiro; Tsunamoto, Hiroshi; Uzu, Kenzo; Yamamoto, Hiroyuki; Yamamoto, Tetsuya; Yokoi, Kiminobu; Yoshida, Chiaki; Watanabe, Nobuhiro; Betsuyaku, Tetsuo; Adachi, Kumiko; Awane, Kouichi; Goto, Daisuke; Sakakibara, Mamoru; Watanabe, Masashi; Ueno, Hideki; Hiroe, Yoshitaka; Matsuo, Koshi; Ayata, Kenji; Fukuda, Ko; Hata, Yoshiki; Hashimoto, Katsushi; Matsumi, Hiroaki; Nikaido, Akira; Okamoto, Shuichi; Sime, Iveta; Stirna, Valters; Reinholde, Ilze; Hansone, Silvija; Kozlovska, Anita; Romanova, Janina; Klincare, Dace; Pontaga, Natalja; Dirmans, Igors; Kalnins, Artis; Upite, Dana; Gersamija, Arcils; Teleznikovs, Arturs; Rozkova, Nadezda; Safro, Jelena; Anguera Camós, Ignasi; Domenico Dallaglio, Paolo; Salguero Bodes, Rafael; Arnbas, Fernando; Borrego, Luis; Marco, Alvaro; Jimenez, Javier Ramos; Gómez-Doblas, Juan José; Pérez Cabeza, Alejandro; Ferreira Gonzålez, Ignacio; Limeres Freire, Javier; Lopez Grau, Merce; Viñolas Prat, Xavier; Moreno Weidmann, Zoraida; Guerra Ramos, Jose Maria; Alonso Martin, Maria Concepcion; Campos Garcia, Bieito; Mogro Carranza, Javier Mauricio; Mendez Zurita, Francisco Javier; Rodriguez Font, Enrique; Gonzales Matos, Carlos Eduardo; García Hernando, Víctor; Lindholm, Carl-Johan; Thulin, Jörgen; Wallén, Håkan; Hagwall, Kristina; Eliasson, Ken; Lundvall, Martin; Olsson, Jens; Kjellman, Björn; Lind, Markus; Johansson, Lars; Svedberg, Niclas; Berglund, Stefan; Söderberg, Julia; Zedigh, Christer; Mooe, Thomas; Axelsson, Mattias; Binsell, Emil; Huber, Daniel; Müller, Christian; Danier, Isabelle; Kühne, Michael; Okamura, Bernhard; Schoepfer, Hadrien; Simmen, Cornelia; Reichlin, Tobias; Chollet, Laurève; Lam, Anna; Wittmer, Severin; Rickli, Hans; Gall, Christian; Hametner, Greta; Intorp, Stephanie; Luescher, Daniel; Haegeli, Laurent; Berg, Jan Christopher; Ebrahimi, Ramin; Auricchio, Angelo; Crljenica, Carmela; Moccetti, Tizziano; Monti, Cristina; Pasotti, Elena; Petrova, Iveta; Rossi, Mariagrazia; Mach, François; Namdar, Mehdi; de Groot, Joris; Proost, Virginnio; Neefs, Joline; Linz, Dominik; van Stipdonk, Twan; den Uijl, Dennis; Alings, Marco; Schaap, Jeroen; Segers, Dolf; Wouters, Noemi; Bartels, Louis; Tieleman, Robert; Pisters, Ron; de Vries, Tim; Selig, Jaap; Kuijper, Aaf; Bot, Pieter; Keijzers, Mitran; Verdel, Gerardus; Tukkie, Raymond; van den Bos, Ewout; Kauer, Floris; Oemrawsingh, Rohit; Stevenhagen, Jeroen; van Es, Jan; Lip, Gregory; Gupta, Dhiraj; Kotalczyk, Agnieszka; Gunstone, Anthony; Brixey, Richard David; Gorog, Diana; Dinarvand, Danial; Gue, Ying; Kanji, Rahim; Memtsas, Vassilios; Senior, Roxy; Bioh, Gabriel; Wong, Yuk-Ki; Child, Nick
Source
The Lancet; April 2022, Vol. 399 Issue: 10333 p1383-1390, 8p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Direct-acting oral anticoagulant use for stroke prevention in atrial fibrillation is limited by bleeding concerns. Asundexian, a novel, oral small molecule activated coagulation factor XIa (FXIa) inhibitor, might reduce thrombosis with minimal effect on haemostasis. We aimed to determine the optimal dose of asundexian and to compare the incidence of bleeding with that of apixaban in patients with atrial fibrillation.