학술논문
Dysfunctional Cortical Gradient Topography in Treatment-Resistant Major Depressive Disorder
Document Type
Article
Author
Source
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging; 20230101, Issue: Preprints
Subject
Language
ISSN
24519022
Abstract
Treatment-resistant depression (TRD) refers to patients with major depressive disorder who do not remit after 2 or more antidepressant trials. TRD is common and highly debilitating, but its neurobiological basis remains poorly understood. Recent neuroimaging studies have revealed cortical connectivity gradients that dissociate primary sensorimotor areas from higher-order associative cortices. This fundamental topography determines cortical information flow and is affected by psychiatric disorders. We examined how TRD impacts gradient-based hierarchical cortical organization.