학술논문
Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6.
Document Type
Article
Author
Source
Proceedings of the National Academy of Sciences of the United States of America; January 1993, Vol. 90 Issue: 2 p755-759, 5p
Subject
Language
ISSN
00278424; 10916490
Abstract
The Ca2+ permeability of the kainate selective glutamate receptor GluR6 depends on the editing of the RNA (or DNA). The unedited version of GluR6, GluR6Q, encodes a glutamine at position 621 (Q/R site) and exhibits a Ca2+/monovalent ion permeability ratio of 1.2, while the edited version of GluR6, GluR6R, encodes an arginine at position 621 and exhibits a permeability ratio of 0.47. Kainate activation of the GluR6 receptor results in currents that are modulated by extracellular calcium ions. Permeability ratios of other divalent ions indicate that the Q/R site is not the only determinant for divalent ion permeability. The level of editing of the receptor will determine the Ca2+ influx through the GluR6 receptor channels and, consequently, may modulate the synaptic activity.