학술논문
Active conservation of noncoding sequences revealed by three-way species comparisons.
Document Type
Article
Author
Source
Genome Research; September 2000, Vol. 10 Issue: 9 p1304-1306, 3p
Subject
Language
ISSN
10889051; 15495469
Abstract
Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.