학술논문
Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial
Document Type
Article
Author
Wolfe, Cameron R; Tomashek, Kay M; Patterson, Thomas F; Gomez, Carlos A; Marconi, Vincent C; Jain, Mamta K; Yang, Otto O; Paules, Catharine I; Palacios, Guillermo M Ruiz; Grossberg, Robert; Harkins, Michelle S; Mularski, Richard A; Erdmann, Nathaniel; Sandkovsky, Uriel; Almasri, Eyad; Pineda, Justino Regalado; Dretler, Alexandra W; de Castilla, Diego Lopez; Branche, Angela R; Park, Pauline K; Mehta, Aneesh K; Short, William R; McLellan, Susan L F; Kline, Susan; Iovine, Nicole M; El Sahly, Hana M; Doernberg, Sarah B; Oh, Myoung-don; Huprikar, Nikhil; Hohmann, Elizabeth; Kelley, Colleen F; Holodniy, Mark; Kim, Eu Suk; Sweeney, Daniel A; Finberg, Robert W; Grimes, Kevin A; Maves, Ryan C; Ko, Emily R; Engemann, John J; Taylor, Barbara S; Ponce, Philip O; Larson, LuAnn; Melendez, Dante Paolo; Seibert, Allan M; Rouphael, Nadine G; Strebe, Joslyn; Clark, Jesse L; Julian, Kathleen G; de Leon, Alfredo Ponce; Cardoso, Anabela; de Bono, Stephanie; Atmar, Robert L; Ganesan, Anuradha; Ferreira, Jennifer L; Green, Michelle; Makowski, Mat; Bonnett, Tyler; Beresnev, Tatiana; Ghazaryan, Varduhi; Dempsey, Walla; Nayak, Seema U; Dodd, Lori E; Beigel, John H; Kalil, Andre C; Wahid, Lana; Walter, Emmanuel B.; Belur, Akhila G.; Dreyer, Grace; Patterson, Jan E.; Bowling, Jason E.; Dixon, Danielle O.; Hewlett, Angela; Odrobina, Robert; Pupaibool, Jakrapun; Mocherla, Satish; Lazarte, Suzana; Cayabyab, Meilani; Hussein, Rezhan H.; Golamari, Reshma R.; Krill, Kaleigh L.; Rajme, Sandra; Riska, Paul F.; Zingman, Barry S.; Mertz, Gregory; Sosa, Nestor; Goepfert, Paul A.; Berhe, Mezgebe; Dishner, Emma; Fayed, Mohamed; Hubel, Kinsley; Martinez-Orozco, José Arturo; Bautista Felix, Nora; Elmor, Sammy T.; Bechnak, Amer Ryan; Saklawi, Youssef; Van Winkle, Jason W.; Zea, Diego F.; Laguio-Vila, Maryrose; Walsh, Edward E.; Falsey, Ann R.; Carvajal, Karen; Hyzy, Robert C.; Hanna, Sinan; Olbrich, Norman; Traenkner, Jessica J.; Kraft, Colleen S.; Tebas, Pablo; Baron, Jillian T; Levine, Corri; Nock, Joy; Billings, Joanne; Kim, Hyun; Elie-Turenne, Marie-Carmelle; Whitaker, Jennifer A.; Luetkemeyer, Anne F.; Dwyer, Jay; Bainbridge, Emma; Gyun Choe, Pyoeng; Kyung Kang, Chang; Jilg, Nikolaus; Cantos, Valeria D; Bhamidipati, Divya R.; Nithin Gopalsamy, Srinivasa; Chary, Aarthi; Jung, Jongtak; Song, Kyoung-Ho; Kim, Hong Bin; Benson, Constance A.; McConnell, Kimberly; Wang, Jennifer P.; Wessolossky, Mireya; Perez, Katherine; Eubank, Taryn A; Berjohn, Catherine; Utz, Gregory C.; Jackson, Patrick E.H.; Bell, Taison D.; Haughey, Heather M.; Moanna, Abeer; Cribbs, Sushma; Harrison, Telisha; Colombo, Christopher J.; Schofield, Christina; Colombo, Rhonda E.; Tapson, Victor F.; Grein, Jonathan; Sutterwala, Fayyaz; Ince, Dilek; Winokur, Patricia L.; Fung, Monica; Jang, Hannah; Wyles, David; Frank, Maria G.; Sarcone, Ellen; Neumann, Henry; Viswanathan, Anand; Hochman, Sarah; Mulligan, Mark; Eckhardt, Benjamin; Carmody, Ellie; Ahuja, Neera; Nadeau, Kari; Svec, David; Macaraeg, Jeffrey C.; Morrow, Lee; Quimby, Dave; Bessesen, Mary; Nicholson, Lindsay; Adams, Jill; Kumar, Princy; Lambert, Allison A.; Arguinchona, Henry; Alicic, Radica Z.; Saito, Sho; Ohmagari, Norio; Mikami, Ayako; Chien Lye, David; Hong Lee, Tau; Ying Chia, Po; Hsieh, Lanny; Amin, Alpesh N.; Watanabe, Miki; Candiotti, Keith A.; Castro, Jose G.; Antor, Maria A.; Lee, Tida; Lalani, Tahaniyat; Novak, Richard M.; Wendrow, Andrea; Borgetti, Scott A.; George, Sarah L.; Hoft, Daniel F.; Brien, James D.; Cohen, Stuart H.; Thompson, George R.; Chakrabarty, Melony; Guirgis, Faheem; Davey, Richard T.; Voell, Jocelyn; Strich, Jeffrey R.; Lindholm, David A.; Mende, Katrin; Wellington, Trevor R.; Rapaka, Rekha R.; Husson, Jennifer S.; Levine, Andrea R.; Yen Tan, Seow; Shafi, Humaira; Chien, Jaime M F; Hostler, David C.; Hostler, Jordanna M.; Shahan, Brian T.; Adams, David H.; Osinusi, Anu; Cao, Huyen; Burgess, Timothy H.; Rozman, Julia; Chung, Kevin K.; Nieuwoudt, Christina; El-Khorazaty, Jill A.; Hill, Heather; Pettibone, Stephanie; Gettinger, Nikki; Engel, Theresa; Lewis, Teri; Wang, Jing; Deye, Gregory A.; Nomicos, Effie; Pikaart-Tautges, Rhonda; Elsafy, Mohamed; Jurao, Robert; Koo, Hyung; Proschan, Michael; Yokum, Tammy; Arega, Janice; Florese, Ruth
Source
The Lancet Respiratory Medicine; September 2022, Vol. 10 Issue: 9 p888-899, 12p
Subject
Language
ISSN
22132600; 22132619
Abstract
Baricitinib and dexamethasone have randomised trials supporting their use for the treatment of patients with COVID-19. We assessed the combination of baricitinib plus remdesivir versus dexamethasone plus remdesivir in preventing progression to mechanical ventilation or death in hospitalised patients with COVID-19.