학술논문
Antagonism of the cytotoxic but not antiviral effects of ara-sangivamycin by adenosine
Document Type
Article
Author
Source
Antimicrobial Agents and Chemotherapy; September 1989, Vol. 33 Issue: 9 p1606-1608, 3p
Subject
Language
ISSN
00664804; 10986596
Abstract
Inhibition of DNA synthesis by ara-sangivamycin was antagonized by adenosine. The 50% inhibitory concentrations increased 1.6- to 32-fold in the presence of 1.0 to 50 microM adenosine, respectively. In contrast, the inhibition of human cytomegalovirus replication by ara-sangivamycin was not antagonized by as much as 50 microM adenosine. This suggests that different enzymes were responsible for the phosphorylation of ara-sangivamycin in uninfected and infected cells.