학술논문
Modified carbon flux during oxygen limited growth of Corynebacterium glutamicumand the consequences for amino acid overproduction
Document Type
Article
Author
Source
Biotechnology Letters; May 1993, Vol. 15 Issue: 5 p449-454, 6p
Subject
Language
ISSN
01415492; 15736776
Abstract
The amino acid producing bacterium Corynebacterium glutamicumaccumulated lactate, succinate and acetate under oxygen-limited growth conditions. Significant restructuring of carbon flux through the central metabolic pathways occurred with a notable decrease in pentose pathway flux and the operation of the TCA cycle in a reductive mode. Simultaneous consumption of residual sugar and organic acids took place when oxygen sufficient conditions were restored though amino acids yields were significantly perturbed.