학술논문
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial
Document Type
Article
Author
Chamberlain, James M; Kapur, Jaideep; Shinnar, Shlomo; Elm, Jordan; Holsti, Maija; Babcock, Lynn; Rogers, Alex; Barsan, William; Cloyd, James; Lowenstein, Daniel; Bleck, Thomas P; Conwit, Robin; Meinzer, Caitlyn; Cock, Hannah; Fountain, Nathan B; Underwood, Ellen; Connor, Jason T; Silbergleit, Robert; Gray, Emily; Gunter, Sonya; Fansler, Amy; Stevenson, Valerie; Bengelink, Erin; Harney, Deneil; Speers, Mickie; Black, Joy; Fisher, Natalie; Harsh, Donna; Ramakrishnan, Arthi; Harris, Lindsey; Bozeman, Nia; Spiteri, Aimee; Palesch, Yuko; Tillman, Holly; Zhao, Wenle; Pauls, Qi; Arnaud, Chris; Dillon, Catherine R.; Riley, Jodie; Alford, Teldon; Conner, Cassidy; Coles, Lisa; Sathe, Abhi; Janis, Scott; Hartman, Adam; Fureman, Brandy; Trinka, Eugen; Treiman, David; Wright, David; Ratcliff, Jonathan; Hall, Alex; Williams, Alaina; Simon, Harold; Stanley, Nicholas; Humphries, Roger; Mims, Theresa; Short, Joann; Jones, Elizabeth; Ottman, Misty; Gentile, Nina; Isenberg, Derek; Reimer, Hannah; Sayoc Kalugdan, Vernon; Hemphill, Claude; Yi Madhok, Debbie; Duncan, Jeany; Randazzo, Dominica; Quinn, James; Visweswaran, Anita; Mann, Rosen; Adeoye, Opeolu; McMullan, Jason; Foreman, Brandon; Keegan, Sara; Biros, Michelle; Driver, Brian; Hendrickson, Audrey; Stang, Jamie; Lewandowski, Christopher; Miller, Joseph; Chaudhry, Kaleem; Berry, Shannen; Warden, Craig; Blake, Rachel; Cook, Jennifer NB; Sabolick, Erin; Selman, Antoine; Kissman, Katrina; Moore, Monica; Huff, J. Stephen; Becker, Lea; Claassen, Jan; Velazquez, Angela; Falo, Cristina; Coralic, Zlatan; Grupp-Phelan, Jackie; Baren, Jill; Ellison, Angela; Woodford, Ashley; Samba, Ima; Kittick, Marlena; Riviello, Ralph; Massey, John; Bonacquisti, Lisa; Levine, Steven; Motov, Sergey; Fromm, Christian; Hossain, Rukhsana; Likourezos, Antonios; Pushkar, Illya; Terndrup, Thomas; Khaliqdina, Salman; Hill, Michael; Peterson, Bjorn; Terwilliger, Alexia; Holm, Joseph; Wicklund, Kyra; Wewerka, Sandi; Welch, Robert; Pearson, Claire; Kumar, Vijaya Arun; Ayaz, Farhan; Bhuiyan, Saikat; Mika, Valerie H.; Morgan, Lola; Jones, Floyd; Dishman, Lorraine; Henry, Thomas; Erickson, Ford; Staugaitis, Abbey; Lawyer, Chloe; Miller, Kathleen; Callaway, Clif; Urban, Alexandra; DiFiore, Sara; Adams, Peter; Baum, Brian; Nomura, Jason; Davis, Barbara; Aufderheide, Tom; Emmrich, Amanda; Mena, Melissa; Labinski, Jacob; Ogedegbe, Chinwe; McCarthy, Diana; Villot-Santiago, Arelis; Goldstein, Joshua; Rosenthal, Eric S.; Cohen, Abigail; Mei Su, Chen; Tirrell, Greg; Howell, Melissa; Hendrickson, Marissa; Nerheim, Dan; Jaton, Eric; Biney, Barbara; Gibson, Christopher; Dahlmeier, Erica; Blackburn, Katherine (Lamond); Vaughan-Ogunlusi, Oluwarotimi (Tim); Zehtabchi, Shahriar; Sinert, Richard; Petty, Bryce; Warden, Craig; Youngquist, Scott; Carlson, Margaret; Gilles, Nadege; Weingast, Sarah (Zelonis); Stern, Barney; Hopp, Jennifer; Ganley, Virginia; Ornato, Joseph; Hogan, Christopher; Payne, Alan; Shreve, Kate; Dayan, Peter; Kuppermann, Nathan; Denninghoff, Kurt; Stanley, Rachel; Ruddy, Richard; Lerner, E. Brooke; Dean, J. Michael; Casper, Charles; Nigrovic, Lise; Schalick, Walt; Nelson, Doug; Thomas, Bobbe; Okada, Pamela; Lee, Amanda; Truesdale, Natasha; Chan, Steven; Naresh, Mhadhumithaa; Robinson, Venita; Hwang, Jieun; Carlston, Kristi; Dela Cruz, Michael; Harbour, Toni; Karki, Reena; Cohen, Daniel M.; Nowakowski, Amy; Lin, Cindy; Fisher Kenny, Erin; Steele, Dale; Merck, Lisa H.; Ryan, Erin; Basso, Kristin; D'Urso, Lesley (Wasilewski); Brown, Kathleen; Nauman, Gina; Ledda, Matthew; Gillen, Sean; Grant, Vanessa; Vance, Cheryl; Nishijima, Daniel K.; Pimenta, Kyle; Herzog, Noelle; Bennett, Jonathan; Eisenhart, Christine; Thomas, Danny; Wagner, Duke; Hickey, Robert W.; Azrak, Rose; Rubalcava, Daniel; Mondragon, Juan; Gonzalez, Victor; Khalil, Maha; Pearson, Claire; Kumar, Vijaya Arun; Hart, Kristina; Parker, Sara; Lumba-Brown, Angela; Quayle, Kim; Chinta, Sri; Robinson, Debra; Kwok, Maria; Peery, Brooke; Ochs, Julie; Suarez, Leonor
Source
The Lancet; April 2020, Vol. 395 Issue: 10231 p1217-1224, 8p
Subject
Language
ISSN
01406736; 1474547X
Abstract
Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in children to compare outcomes in three age groups.