학술논문
Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial
Document Type
Article
Author
Bohula, Erin A; Scirica, Benjamin M; Inzucchi, Silvio E; McGuire, Darren K; Keech, Anthony C; Smith, Steven R; Kanevsky, Estella; Murphy, Sabina A; Leiter, Lawrence A; Dwyer, Jamie P; Corbalan, Ramon; Hamm, Christian; Kaplan, Lee; Nicolau, Jose Carlos; Ophuis, Ton Oude; Ray, Kausik K; Ruda, Mikhail; Spinar, Jindrich; Patel, Tushar; Miao, Wenfeng; Perdomo, Carlos; Francis, Bruce; Dhadda, Shobha; Bonaca, Marc P; Ruff, Christian T; Sabatine, Marc S; Wiviott, Stephen D; Sabatine, Marc S; Wiviott, Stephen D; Scirica, Benjamin M; Inzucchi, Silvio; Keech, Anthony; McGuire, Darren K; Smith, Steven R; Satlin, Andrew; Brown, Conville; Budaj, Andrzej; Corbalan, Ramon; Dwyer, Jamie; Garcia-Castillo, Armando; Gupta, Milan; Hamm, Christian; Kaplan, Lee; Keech, Anthony; Leiter, Lawrence A; Nicolau, Jose Carlos; Oude Ophuis, Ton; Ray, Kauski; Ruda, Mikhail; Scirica, Benjamin M; Spinar, Jindrich; Weissman, Neil; White, Harvey D; Wiviott, Stephen D; Amerena, J; Arstall, M; Colquhoun, D; Jayasinghe, R; Lee, A; Lehman, R; Moses, R; Proietto, J; Purnell, P; Waites, J; Blombery, P; Cross, D; Worthley, M; d'Emden, M; Selvanayagam, J; Oqueli, RE; Whelan, A; Garrahy, P; de Looze, F; Ninio, D; Horowitz, J; William, M; Suranyi, M; Wittert, G; Le May, M; Pandey, AS; Vizel, S; Labonte, R; Beaudry, Y; Fortin, C; Bell, A; Kouz, S; St-Amour, É; Bata, I; St Maurice, F; Chehayeb, R; Constance, C; Wong, G; Hess, A; Liutkus, J; Poirier, P; Teitelbaum, I; Berlingieri, J; Cha, J; Hartleib, M; Heffernan, M; Twum-Barima, D; Pandith, V; Aronson, R; Goldenberg, R; Ajala, B; Jain, A; Ross, S; Bajaj, H; Khandwala, H; Yared, Z; Gupta, N; Bédard, J; Wharton, S; Blouin, F; Savard, D; Shukla, D; Cobos, J; Godoy, G; Perez, L; Pincetti, C; Saavedra Guajardo, V; Varleta, P; Conejeros, C; Lanas, F; Bayram Llamas, E; Cardona Muñoz, E; Garcia, R; Garza Ruiz, J; Llamas Esperon, G; Lopez Rosas, E; Melendez Mier, G; Ramos, G; Hart, H; Scott, D; Ternouth, I; Benatar, J; Elliott, J; Cutfield, R; Manning, P; Williams, M; Ferrier, K; Scott, R; Wilson, S; Leikis, R; Nirmalaraj, BK; Krzyżagórska, E; Miękus, P; Bronisz, M; Mirek-Bryniarska, E; Łanda, K; Stasiewski, A; Żechowicz, T; Zytkiewicz-Jaruga, D; Korecki, J; Ogórek, M; Pawłowicz, L; Piepiorka, M; Skierkowska, J; Stankiewicz, A; Szyprowska, E; Witek, R; Bochenek, A; Kończakowski, P; Wojnowski, Ł; Wujkowski, M; Cymerman, K; Korzeniak, R; Mąder, P; Mikłaszewicz, B; Stachlewski, P; Goch, A; Pomiećko, W; Skórski, M; Romanowski, L; Jusiak, K; Laskowska-Derlaga, E; Bijata-Bronisz, R; Kaźmierczak, J; Goldberg, R; Henderson, D; Korban, E; Rohr, K; Claxton, E; Weiss, R; Angiolillo, D; Boccalandro, F; Chu, K; Thorn, E; Randhawa, P; Singh, N; Bittar, G; Guarnieri, T; Saeed, S; Sharma, S; Shepard, M; French, W; Desai, P; Bernstein, R; Rogers, W; Singal, R; Schneider, R; Shanes, J; Ong, S; Condit, J; Donahoe, S; Brill, D; Einhorn, D; Ebrahimi, R; Labroo, A; Graf, R; Scott, J; Hoekstra, J; Jetty, P; Luckasen, G; O'Donnell, P; Gonte, W; Pomposini, D; Quadrel, M; Koren, M; Schlager, D; Schramm, E; Singal, D; Lupovitch, S; Soni, A; Seigel, P; Roberts, J; Soufer, J; Reza, S; Quinlan, E; Moretto, T; First, B; Khan, M; Chilka, S; Colfer, H; Teklinski, A; Wallace-Wilding, K; Ellison, H; Muse, D; Aronoff, S; Higgins, A; Patel, S; Elinoff, V; Karim, A; Awasty, V; Chuang, R; Roseman, H; Dugano-Daphnis, P; Albert, M; Sheikh, K; Bays, H; Kaster, S; Goldstein, M; Rubino, D; Calatayud, G; Snyder, H; Williams, T; Hershon, K; Hagan, M; Isserman, S; Kahn, B; Anderson, J; Gimness, MP; Raisinghani, A; Christina, M; Raikhel, M; Gillespie, E; Portnay, E; Heiman, M; Qureshi, M; Lee, J; Blonder, R; Cucher, F; Miller, G; Kotlaba, D; Cornett, G; Beavins, J; Augenbraun, C; Reinhardt, S; Bartkowiak, A; Salacata, A; Blevins, T; Benjamin, S; Diener, J; George, W; Barker, B; Richwine, R; Baldari, D; Alfieri, A; Barreto, A; Zhang, L; Shah, R; Hendrix, E; Subramaniyam, V; Hurley, S; Lillestol, M; O'Donoghue, M; Shayani, S; Ryan, E; Call, R; Zemel, L; Chang, A; Kivitz, A; Freyne, B; Bland, V; Shore, K; Mostel, E; Uzoaga, E; Andrawis, N; Gabra, N; Ghitis, A; Sabatino, K; Browder, D; Varma, S; Smith, S; Fink, R; Aycock, GR; Doty, WD; Alfonso, T; Eshaghian, S; Karlsberg, R; Zarich, S; Landau, C; McKenzie, M; Krause, R; Davis, W; Haddad, T; Voyce, S; Alford, C; LeDoux, J; O'Dea, D; McKenzie, M; Park, J; Aroda, V; Getaneh, A; Graham, B; Bhagwat, R; Korn, D; Ruoff, G; Wiseman, A; Lieber, I; Fialkow, J; Gonzalez-Campoy, JM; Bayron, C; Bertolet, B; Lash, J; Gerrish, C; Robertson, D; Rosenfeld, J; Seidner, M; Agaiby, J; Silverfield, J; Sugimoto, D; Lubin, B; Alhaddad, M; Lui, H; Lakin, G; Chokshi, S; Donovan, D; Felten, W; Minton, S; Kimmelstiel, C; Kuvin, J; Still, C; Byars, W; Talano, J; Desai, V; Bradley, AJ; Baker, S; Chane, M; Mercado, A; Baron, S; Harris, B; Mayer, N; Concha, M; Carr, K; Chaykin, L; Willis, J; Clay, A; Fenstad, E; Furda, J; Peterson, P; Chang, M; Aronne, L; Jones, D; Prashad, R; Benson, M; Stegemoller, R; Longshaw, K; Saleh, J; Jennings, W; Detweiler, R; Viswanath, D; Patel, R; Miller, G; Lederman, S; Weinstein, D; Korabathina, R; Singh, V; Rosen, J; Estevez, R; Levin, P; McNeill, R; Kalen, V; Reed, J; Ashley, R; Herman, L; Tsai, Y; Kayne, D; White, A; Hussain, I; Tami, L; Cohen, K; Robinson, J; Sharma, S; Fuchs-Ertman, D; Platt, G; Belardo, L; Reddy, R; Rosendorff, C; Saba, F; Powell, S; Anderson, K; Abidi, M; Rezkalla, S; Paraschos, A; Wilson, J; Moursi, M; Shah, A; Patel, R; Nadar, V; Stonesifer, L; Bialow, M; Cannon, K; Ellison, W; Stedman, M; Brown, J; Harper, W; Lucas, KJ; DiGiovanna, M; Rodbard, H; Biscoveanu, M; Davis, C; Hall, J; Littlefield, R; Gorman, T; Kereiakes, D; Chang, FM; Tatu, H; Cheung, D; Kaine, J; Knutson, T; Logemann, T; Pueblitz, G; Bianco, J; Henson, B; Neustel, M; Gelernt, M; Nelson, W; Moriarty, K; Lefebvre, G; Maw, K; Rink, L; Behn, P; Studdard, H; Argoud, G; O'Connor, T; Krichmar, P; Raad, G; Pereles-Ortiz, J; Sorli, C; Cohen, A; Pettis, K; Cavanaugh, B; Phillips, C; Wahlen, J; Radin, D; Rider, J; Kosinski, E; Leimbach, W; Odhav, A; Hakas, J; Tan, A; Howell, M; Wombolt, D; Fishman, N; Shah, P; Wylie, P; Arauz-Pacheco, C; Cavale, A; George, A; Kroll, R; Krantzler, J; Tahirkheli, N; Jabro, M; Newell, M; Mullen, P; Gencheff, N; Meli, J; Vora, K; Kotek, L; Pyzdrowski, K; Paez, H; Moran, J; Tannenbaum, A; Deck, K; Busch, R; Levinson, L; Azizad, M; Whitaker, J; Fox, B; Huffman, C; Ashraf, M; Diogo, J; Kushner, R; Tallet, J; Channamsetty, V; Suh, D; Atieh, M; Navas, J; Young, V; Shaw, S; Dor, I; Duffy, B; Rubin, P; Lewis, D; Kaye, W; Benton, R; Burbano, J; Hotchkiss, D; Magno, A; Alberton, A; Collins, J; Alvarado, O; Stich, M; Mahal, S; Liu, J; Hong, M; Dy, J; Block, B; Lamantia, J; Pritchard, J; Davis, M; Srivastava, S; Bilazarian, S; Rosario, R; McCartney, M; Blumberg, V; Rajan, R; Martin, E; Wright, S; White, A; Levinson, L; Brinson, C; Johnston, J; Wilson, S; Graves, M; Dominguez, M; McKenzie, W; Abadier, R; Tran, C; Castello, R; Morawski, E; White, J; Morris, F; Perez, A; Trueba, P; Sanchez, M; Andersen, J; Kastelic, R; Khan, J; Rodriguez, H; Izquierdo, W; Matias, A; Essandoh, L; Ince, C
Source
The Lancet; November 2018, Vol. 392 Issue: 10161 p2269-2279, 11p
Subject
Language
ISSN
01406736; 1474547X
Abstract
There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has been shown to facilitate sustained weight loss in obese or overweight patients. We aimed to evaluate the long-term effects of lorcaserin on diabetes prevention and remission.