학술논문
Germline rare variants of lectin pathway genes predispose to asymptomatic SARS-CoV-2 infection in elderly individuals
Document Type
Article
Author
D’Alterio, Giuseppe; Lasorsa, Vito Alessandro; Bonfiglio, Ferdinando; Cantalupo, Sueva; Rosato, Barbara Eleni; Andolfo, Immacolata; Russo, Roberta; Esposito, Umberto; Frisso, Giulia; Abete, Pasquale; Cassese, Gian Marco; Servillo, Giuseppe; Gentile, Ivan; Piscopo, Carmelo; Della Monica, Matteo; Fiorentino, Giuseppe; Boccia, Angelo; Paolella, Giovanni; Ferrucci, Veronica; de Antonellis, Pasqualino; Siciliano, Roberto; Asadzadeh, Fathem; Cerino, Pellegrino; Buonerba, Carlo; Pierri, Biancamaria; Zollo, Massimo; Iolascon, Achille; Capasso, Mario
Source
Genetics in Medicine; 20220101, Issue: Preprints
Subject
Language
ISSN
10983600; 15300366
Abstract
Emerging evidence suggest that infection-dependent hyperactivation of complement system (CS) may worsen COVID-19 outcome. We investigated the role of predicted high impact rare variants — referred as qualifying variants (QVs) — of CS genes in predisposing asymptomatic COVID-19 in elderly individuals, known to be more susceptible to severe disease.