학술논문
Effects of iEW Synthetic Peptide Isomers on Bone Marrow Colony-Forming Capacity In Vivo
Document Type
Article
Author
Source
Bulletin of Experimental Biology and Medicine; September 2005, Vol. 140 Issue: 3 p348-351, 4p
Subject
Language
ISSN
00074888; 15738221
Abstract
Studies of cooperative effects of D- or L-isomers of iEW dipeptide and neuraminidase on the number of splenic CFU, comparison of the peptide effects on CD34+ cells and splenic CFU, and evaluation of the effects of iEW D- or L-isomers on parameters of T-cell activation showed that interactions of L-(iEW) and D-(iEW) with CD34+ surface receptors are realized through the same mechanism, while their different biological effects on hemopoietic precursor cells in vivo can be explained by their different influence on T-component of the microenvironment.