학술논문
Effects of structural and “mixed” isomers of Glu-Trp dipeptide on normal hemopoietic stem cells
Document Type
Article
Author
Source
Bulletin of Experimental Biology and Medicine; February 2006, Vol. 141 Issue: 2 p250-253, 4p
Subject
Language
ISSN
00074888; 15738221
Abstract
Abstract: We studied the effects of optical (dd-, ll-, dl-, and ld-dipeptides with α-bond, EW) structural isomers and cyclic (dd-, ll-, dl-, and ld-dipeptides with γ-bond, iEW) analogs of Glu-Trp synthetic dipeptide on the population of normal hemopoietic stem cells. Dipeptides containing lGlu (lGlu-lTrp, lGlu-dTrp) injected to mice were inert towards committed bone marrow CFU-S; dGlu-containing dipeptides (dGlu-dTrp, dGlu-lTrp) inhibited the growth of CFU-S-8; and LiGlu-dTrp stimulated these cells. Inhibitory or stimulatory effects of optical and chemical isomers of Glu-Trp dipeptide are determined by optical orientation and nature of peptide bond of Glu residue. The effects of cyclic and mixed peptides towards colony formation are similar to those of the corresponding linear dipeptides.